INT146804

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.21
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Acp5) lysosome (Acp5)
Anatomy Link Frequency
regulatory T cells 6
osteoclasts 2
parathyroid 2
Acp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 45 88.80 High High
Arthritis 37 87.60 High High
palliative 1 27.36 Quite Low
agonist 20 26.20 Quite Low
Pain 2 25.36 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 16 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 96 96.48 Very High Very High Very High
Pressure And Volume Under Development 9 94.40 High High
INFLAMMATION 39 88.80 High High
Arthritis 53 87.60 High High
Breast Cancer 4 84.80 Quite High
Bone Cancer 2 83.52 Quite High
Metastasis 2 81.08 Quite High
Cancer 7 80.80 Quite High
Death 16 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Positive_regulation (increases) of Gene_expression (expression) of TRAP in osteoclasts associated with hypercalcemia
1) Confidence 0.12 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.09 Pain Relevance 0.28
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (regulatory T cells) of Gene_expression (transferase) of TRAP in regulatory T cells associated with systemic lupus erythematosus
2) Confidence 0.09 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (transferase) of Gene_expression (transferase) of TRAP in regulatory T cells associated with systemic lupus erythematosus
3) Confidence 0.09 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
2; Runx2: Runt related transcription factor 2; Th17: T helper 17; TRAP: telomeric repeat amplification protocol; Tregs: regulatory T cells; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling; SHED: Stem cells from human exfoliated deciduous teeth; SLE: systemic lupus erythematosus; sRANKL: soluble receptor activator for nuclear factor ?
Positive_regulation (mediated) of Gene_expression (transferase) of TRAP in regulatory T cells associated with systemic lupus erythematosus
4) Confidence 0.09 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0.27 Pain Relevance 0
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Positive_regulation (increased) of Gene_expression (levels) of acid phosphatase 5b in parathyroid associated with hypercalcemia
5) Confidence 0.06 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.33 Pain Relevance 0

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