INT146805

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.20
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth)
Anatomy Link Frequency
parathyroid 4
skeleton 2
Pth (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 72.32 Quite High
palliative 2 27.36 Quite Low
carpal tunnel syndrome 1 15.84 Low Low
Sciatica 1 8.96 Low Low
spinal stenosis 1 7.60 Low Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 16 99.48 Very High Very High Very High
Rickets 8 90.40 High High
Osteoporosis 6 89.60 High High
Breast Cancer 8 84.80 Quite High
Frailty 4 83.00 Quite High
Metastasis 4 81.08 Quite High
Targeted Disruption 4 81.04 Quite High
Cancer 14 80.80 Quite High
Death 2 75.56 Quite High
Disease Progression 2 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Positive_regulation (increased) of Gene_expression (levels) of PTH in parathyroid associated with hypercalcemia
1) Confidence 0.49 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.33 Pain Relevance 0
On day 0, mice receiving Low-Ca had increased serum parathyroid hormone (PTH) and tartrate-resistant acid phosphatase 5b levels, indicating secondary hyperparathyroidism and high bone turnover, which was maintained until day 17.
Positive_regulation (increased) of Gene_expression (levels) of parathyroid hormone in parathyroid associated with hypercalcemia
2) Confidence 0.49 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17909065 Disease Relevance 1.33 Pain Relevance 0
In mild vitamin D deficiency, the elevation of serum PTH increases the conversion of 25(OH)D to 1,25(OH)D to compensate for the insufficient 25(OH)D available; however, elevation in PTH increases bone resorption, leading to additional bone loss [19].
Positive_regulation (increases) of Gene_expression (elevation) of serum PTH associated with hypercalcemia
3) Confidence 0.37 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.98 Pain Relevance 0.07
Also, studies find the increases in bone formation induced by antisclerostin antibody, unlike PTH, not associated with increases in bone resorption in the aged rodent skeleton.
Positive_regulation (induced) of Gene_expression (antibody) of PTH in skeleton associated with hypercalcemia
4) Confidence 0.15 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2957275 Disease Relevance 0.57 Pain Relevance 0

General Comments

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