INT146807

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 11.80
Pain Relevance 4.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL18) extracellular space (CCL18) extracellular region (CCL18)
cell-cell signaling (CCL18)
Anatomy Link Frequency
endothelial cells 3
CLC 2
joints 2
macrophages 1
dendritic cells 1
CCL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 701 100.00 Very High Very High Very High
rheumatoid arthritis 686 99.98 Very High Very High Very High
Inflammation 354 99.76 Very High Very High Very High
Inflammatory mediators 28 98.64 Very High Very High Very High
cytokine 96 78.68 Quite High
aspirin 25 77.00 Quite High
Demyelination 12 60.96 Quite High
Inflammatory response 24 56.96 Quite High
Angina 6 50.00 Quite Low
Central nervous system 50 43.72 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 686 99.98 Very High Very High Very High
INFLAMMATION 406 99.76 Very High Very High Very High
Rhinitis 310 99.24 Very High Very High Very High
Chronic Sinusitis 70 97.60 Very High Very High Very High
Arthritis 14 97.40 Very High Very High Very High
Asthma 85 97.32 Very High Very High Very High
Polyps 65 93.08 High High
Nasal Polyps 30 90.60 High High
Eczema 155 90.48 High High
Necrosis 32 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar levels of CCL18 were released into supernatant of RA blood or SF PMN co-cultured with endothelial cells (data not shown).
Localization (released) of CCL18 in endothelial cells associated with rheumatoid arthritis
1) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.17 Pain Relevance 0.08
Interestingly, as shown in Figure 4a, neither blood PMN from healthy donors nor blood PMN from patients with RA released significant amounts of CCL18 in response to IL-10 alone or to a combination of IL-10 and TNF-?
Localization (released) of CCL18 in blood associated with rheumatoid arthritis
2) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.28 Pain Relevance 0.14
However, CCL18 could be induced by stimulation of SF PMN with IL-10; indeed, IL-10 in combination with vitamin D3 even enhanced CCL18 release.
Localization (release) of CCL18
3) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.37
The results (Figure 4a) showed no spontaneous release of CCL18 by SF PMN.
Localization (release) of CCL18
4) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.43 Pain Relevance 0.42
To determine whether extravasation might have a role in the induction of CCL18 release, PMN and PBMC from healthy donors were co-cultured with the endothelial cell line EA-hy.926.
Localization (release) of CCL18 in endothelial cell
5) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.21 Pain Relevance 0.11
As IL-10 and vitamin D3 are known to have anti-inflammatory properties [41,42], the release of CCL18 induced by these mediators might contribute to a suppression of joint inflammation.
Localization (release) of CCL18 in joint associated with inflammation and arthritis
6) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.58 Pain Relevance 0.29
Results in Figure 5a revealed high levels of CCL18 in culture supernatants of PMN or PBMC co-cultured with endothelial cells, whereas no release of CCL18 was observed when PMN and EA-hy.926 cells were incubated separately from each other in Boyden chambers.
Neg (no) Localization (release) of CCL18 in endothelial cells
7) Confidence 0.78 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.21 Pain Relevance 0.11
In comparison, recruited SF PMN from patients with RA were sensitized for CCL18 production, because IL-10 alone was sufficient to induce CCL18 release.
Localization (release) of CCL18 in PMN associated with rheumatoid arthritis
8) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.51 Pain Relevance 0.27
Levels of CC chemokine ligand (CCL)-5 (also known as RANTES [regulated on activation, normally T-cell expressed, and secreted]; 32.7 versus 23.1 ng/mL, P=0.018) and CCL18 (also known as PARC [pulmonary and activation-regulated chemokine]; 104.4 versus 53.7 ng/mL, P=0.011) were significantly elevated in patients with refractory ischemic symptoms versus stabilized patients.
Localization (secreted) of CCL18 in T-cell
9) Confidence 0.70 Published 2007 Journal Circulation Section Body Doc Link 17909104 Disease Relevance 0.34 Pain Relevance 0
was found to induce neither the release of CCL18 (Figure 5b) nor the expression of CCL18 mRNA (Figure 5c), suggesting that CCL18 derives from PMN.
Localization (release) of CCL18
10) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.14 Pain Relevance 0.07
Incubation with both IL-10 and vitamin D3 produced the release of even more CCL18 by PMN preincubated with SF.


Localization (release) of CCL18
11) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.21 Pain Relevance 0.11
In contrast, SF PMN from patients with RA did not release CCL18 in response to TNF-?.
Neg (not) Localization (release) of CCL18 associated with rheumatoid arthritis
12) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.34
Release of the chemokine CCL18 has been widely attributed to antigen-presenting cells, including macrophages and dendritic cells.
Localization (Release) of chemokine CCL18 in macrophages associated with chemokine
13) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.33
These results suggest a release of the T cell-attracting CCL18 by PMN when recruited to diseased joints.
Localization (release) of CCL18 in joints
14) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.40 Pain Relevance 0.21
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
15) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.60 Pain Relevance 0.13
The CCL18 gene is also located near the eotaxin-1 and MCP genes cluster at chromosome 17q11.2.
Localization (located) of CCL18 gene
16) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 1.11 Pain Relevance 0.26
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CCL18 in monocyte associated with chemokine
17) Confidence 0.57 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.83 Pain Relevance 0.18
Our qRT-PCR results for CCL13, CCL18, CRISP3, EMR3, and IL1RL1 (ST2) (Figure 2) and the increased presence of CLC (Figure 3) and CCL18 [17] protein in separately collected airway specimens from CRS or asthmatic patients, in accordance with their increased mRNA levels in our aCRSwNP patients, further support the validity of our exon array data.
Localization (presence) of CCL18 in CLC associated with asthma and chronic sinusitis
18) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897889 Disease Relevance 0.64 Pain Relevance 0.12
Release of the chemokine CCL18 has been widely attributed to antigen-presenting cells, including macrophages and dendritic cells.
Localization (Release) of chemokine CCL18 in dendritic cells associated with chemokine
19) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212580 Disease Relevance 0.45 Pain Relevance 0.33
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CCL18 in eosinophil associated with chemokine
20) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.83 Pain Relevance 0.18

General Comments

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