INT14682

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Context Info
Confidence 0.54
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.90
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B3GAT1) carbohydrate metabolic process (B3GAT1)
Anatomy Link Frequency
salivary gland epithelium 2
spinal 1
epithelium 1
salivary gland 1
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 12 99.98 Very High Very High Very High
Pain 13 99.60 Very High Very High Very High
Neuropeptide 16 99.34 Very High Very High Very High
Lasting pain 6 98.92 Very High Very High Very High
analgesia 1 98.88 Very High Very High Very High
Enkephalin 4 98.48 Very High Very High Very High
Cholecystokinin 4 97.60 Very High Very High Very High
Anterior cingulate 1 95.60 Very High Very High Very High
Hippocampus 4 94.48 High High
Analgesic 5 93.68 High High
Disease Link Frequency Relevance Heat
Stress 4 99.84 Very High Very High Very High
Pain 14 99.60 Very High Very High Very High
Malignant Tumors Of Salivary Glands 4 98.52 Very High Very High Very High
Anxiety Disorder 3 98.52 Very High Very High Very High
Vomiting 212 97.98 Very High Very High Very High
Salivary Gland Disease 3 95.40 Very High Very High Very High
Nociception 2 90.20 High High
Urological Neuroanatomy 1 81.20 Quite High
Hyperalgesia 1 73.40 Quite High
Pressure And Volume Under Development 1 72.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional assay based on aequorin-derived luminescence triggered by receptor-mediated changes in Ca2+ levels was used to compare the effect of spantides I-III on SP-, NKA- and NKB-stimulated NK1, NK2 and NK3 receptors, respectively.
Regulation (effect) of NK1
1) Confidence 0.54 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15990182 Disease Relevance 0 Pain Relevance 0.16
The immunoreactivity of anti-neuron-specific enolase (NSE) and anti-Leu-7 on formalin-fixed sections of human salivary gland neoplasms was determined by the avidin-biotin-peroxidase complex method.
Regulation (immunoreactivity) of Leu-7 in salivary gland associated with malignant tumors of salivary glands
2) Confidence 0.50 Published 1990 Journal Pathobiology Section Abstract Doc Link 1701303 Disease Relevance 0.38 Pain Relevance 0.27
Conversely, although imipramine did not provide significant behavioral analgesia, it significantly blocked both pain- and stress-evoked alterations in hippocampal and spinal NK-1 and BDNF gene expression.
Regulation (alterations) of NK-1 in spinal associated with stress, pain and analgesia
3) Confidence 0.44 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.21 Pain Relevance 1.56
The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement.
Regulation (modulate) of NK1 associated with anxiety disorder
4) Confidence 0.44 Published 2010 Journal Pain Section Abstract Doc Link 20137858 Disease Relevance 0.73 Pain Relevance 0.64
The immunoreactivity of anti-neuron-specific enolase (NSE) and anti-Leu-7 on formalin-fixed sections of human fetal salivary gland epithelium was determined by the avidin-biotin-peroxidase complex (ABC) method.
Regulation (immunoreactivity) of Leu-7 in salivary gland epithelium
5) Confidence 0.35 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0 Pain Relevance 0.30
Although the precise mechanism of CINV is not fully understood, it is now believed that acute emesis is caused by peripheral serotonergic pathways, and delayed symptoms by centrally acting substance P acting on NK1 receptors (Fig. 1).
Regulation (acting) of NK1 associated with vomiting and substance p
6) Confidence 0.16 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 1.34 Pain Relevance 0.22
NSE and Leu-7 immunoreactivity in the fetal salivary gland epithelium was observed solitarily or in groups commonly restricted to the developing duct epithelium.
Regulation (immunoreactivity) of Leu-7 in epithelium
7) Confidence 0.15 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.08 Pain Relevance 0.46
In contrast, the incidence of positive cases stained with neuropeptides was lower than those of NSE and Leu-7 immunoreactivity in the human fetal salivary gland epithelium.
Regulation (immunoreactivity) of Leu-7 in salivary gland epithelium associated with neuropeptide
8) Confidence 0.15 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.10 Pain Relevance 0.45
On the other hand, the serum levels of Met-enk, epinephrin, CRF, cortisol and CD57 were not significantly different between the two groups.
Neg (not) Regulation (different) of CD57
9) Confidence 0.06 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11072598 Disease Relevance 0.06 Pain Relevance 0

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