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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.22

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Golgi apparatus (Gtpbp4) GTPase activity (Gtpbp4) ribosome biogenesis (Gtpbp4)
cytoplasm (Gtpbp4) signal transducer activity (Galr1) nucleolus (Gtpbp4)
Anatomy Link Frequency
spinal 1
Galr1 (Rattus norvegicus)
Gtpbp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 1 98.86 Very High Very High Very High
agonist 4 87.08 High High
substantia gelatinosa 2 75.00 Quite High
Action potential 1 71.76 Quite High
antagonist 1 47.84 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 3 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These diverse actions of GalR1 and GalR2 activation on both inhibitory and excitatory neurons are discussed in relation to the known spinal antinociceptive and pro-nociceptive actions of galanin, to the possible association of GalR1 with the inhibitory G-protein, G(i/o) and to report that GalR2 activation suppresses Ca2+ channel currents.
GalR1 Binding (association) of G-protein in spinal associated with nociception and antinociceptive
1) Confidence 0.03 Published 2008 Journal Pain Section Abstract Doc Link 17910903 Disease Relevance 0.17 Pain Relevance 0.22

General Comments

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