INT146829

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 5.73
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mefv) nucleus (Mefv) intracellular (Mefv)
cytoplasm (Mefv)
Anatomy Link Frequency
neutrophil 1
Mefv (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 104 100.00 Very High Very High Very High
Catecholamine 1 93.76 High High
cva 4 90.08 High High
Inflammatory marker 6 89.76 High High
Etanercept 1 87.76 High High
psoriasis 2 87.44 High High
Arthritis 9 83.72 Quite High
anakinra 1 83.44 Quite High
abdominal pain 1 82.84 Quite High
rheumatoid arthritis 6 50.56 Quite High
Disease Link Frequency Relevance Heat
Fever 112 100.00 Very High Very High Very High
INFLAMMATION 106 100.00 Very High Very High Very High
Amyloidosis 9 100.00 Very High Very High Very High
Atherosclerosis 60 95.56 Very High Very High Very High
Cancer 1 90.96 High High
Skin Diseases 2 90.68 High High
Necrosis 1 90.48 High High
Disease 19 90.28 High High
Cv General 3 Under Development 4 90.08 High High
Purpura 2 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pyrin normally blunts neutrophil-mediated inflammation, likely via interleukin-1 (IL-1) downregulation, but is defective in FMF.
Negative_regulation (defective) of FMF in neutrophil associated with inflammation and fever
1) Confidence 0.39 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17911435 Disease Relevance 1.87 Pain Relevance 0.35
Colchicine is proved to be useful in suppression of inflammation in FMF.
Negative_regulation (suppression) of FMF associated with inflammation and fever
2) Confidence 0.10 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Abstract Doc Link PMC2847313 Disease Relevance 1.53 Pain Relevance 0.29
However, the first report on successful treatment of attacks of FMF with colchicine published in 1972 [74] and large clinical trials [75, 76] distinguished colchicine as a drug of choice for prevention of attacks and amyloidosis in FMF.
Negative_regulation (prevention) of FMF associated with amyloidosis and fever
3) Confidence 0.10 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2847313 Disease Relevance 2.34 Pain Relevance 0.31

General Comments

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