INT14688

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Context Info
Confidence 0.46
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.93
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSF3R) extracellular region (CSF3R) cell adhesion (CSF3R)
plasma membrane (CSF3R)
Anatomy Link Frequency
granulocyte 2
lung 1
CSF3R (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 70.80 Quite High
Pain 8 25.00 Low Low
imagery 11 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 99.52 Very High Very High Very High
Choroideremia 166 98.40 Very High Very High Very High
Lung Cancer 9 98.08 Very High Very High Very High
Leukocytosis 30 97.96 Very High Very High Very High
Malignant Neoplastic Disease 2 95.24 Very High Very High Very High
Neutropenia 153 93.32 High High
Body Weight 3 90.80 High High
Muscular Dystrophy 2 90.40 High High
Neutrophil Disorders 22 88.00 High High
Adhesions 3 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of granulocyte colony-stimulating factor (G-CSF) by tumor cells was first identified in lung carcinoma in 1977 [3].
Gene_expression (Production) of granulocyte colony-stimulating factor in lung associated with lung cancer and cancer
1) Confidence 0.46 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1526734 Disease Relevance 1.27 Pain Relevance 0
Recombinant human granulocyte colony-stimulating factor (rG-CSF), produced by Chinese hamster ovary cells, was administered in 69 chemotherapy-induced neutropenic pediatric patients (pts) with malignant tumors.
Gene_expression (produced) of granulocyte colony-stimulating factor in granulocyte associated with malignant neoplastic disease
2) Confidence 0.40 Published 1990 Journal Rinsho Ketsueki Section Abstract Doc Link 1701501 Disease Relevance 0.25 Pain Relevance 0
For normal neutrophil cell maturation, the proliferative action of the granulocyte colony stimulating factor (G-CSF) is necessary [11].
Gene_expression (action) of granulocyte colony stimulating factor in granulocyte
3) Confidence 0.29 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 1.01 Pain Relevance 0
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Gene_expression (expression) of CSF3R associated with choroideremia
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.77 Pain Relevance 0.06
Both used G-CSF had to be stopped when an ANC of ?
Gene_expression (stopped) of G-CSF
5) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628928 Disease Relevance 0.09 Pain Relevance 0
Both used G-CSF had to be stopped when an ANC of ?
Gene_expression (had) of G-CSF
6) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628928 Disease Relevance 0.09 Pain Relevance 0
More recently, a biosimilar non-glycosylated r-metHuG-CSF expressed in Escherichia coli for intravenous (i.v.) and subcutaneous (s.c.) administration was clinically developed by BioGeneriX AG for the treatment of chemotherapy-induced neutropenia.
Gene_expression (expressed) of r-metHuG-CSF associated with neutropenia
7) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628928 Disease Relevance 0.43 Pain Relevance 0

General Comments

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