INT146893

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Dkk1) extracellular region (TNF, Dkk1) plasma membrane (TNF, Dkk1)
signal transduction (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 1 98.08 Very High Very High Very High
Arthritis 2 87.40 High High
Inflammation 1 81.88 Quite High
cINOD 1 73.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 2 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Osteoporosis 1 99.36 Very High Very High Very High
Low Back Pain 1 98.08 Very High Very High Very High
Disease 5 92.96 High High
Arthritis 2 87.40 High High
INFLAMMATION 2 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent evidence suggests that the new bone formation in ankylosing spondylitis may be due to upregulation of Wnt signaling in the osteoblastic pathway secondary to low serum DKK-1 levels, which are further suppressed by tumor necrosis factor inhibitor therapy.
tumor necrosis factor Negative_regulation (suppressed) of DKK-1 associated with spinal inflammation, necrosis, cancer and osteoporosis
1) Confidence 0.01 Published 2007 Journal Curr Rheumatol Rep Section Abstract Doc Link 17915093 Disease Relevance 1.27 Pain Relevance 0.30

General Comments

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