INT146898

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.01
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
Anatomy Link Frequency
kidney 2
CFH (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 92.08 High High
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
bradykinin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemolytic Uremic Syndrome 22 100.00 Very High Very High Very High
Renal Failure 5 99.24 Very High Very High Very High
Lyme Disease 184 99.20 Very High Very High Very High
Sprains And Strains 90 92.76 High High
Anaemia 1 89.88 High High
Thrombocytopenia 3 89.44 High High
Disease 30 81.36 Quite High
Adverse Drug Reaction 1 78.44 Quite High
Hemolytic Anemia 2 74.72 Quite High
Infection 41 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was because the exact type of mutation would help them predict whether a kidney transplant is likely to be successful in treating an individual with aHUS who has developed kidney failure.
Positive_regulation (successful) of aHUS Binding (individual) of in kidney associated with renal failure
1) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1626556 Disease Relevance 0.37 Pain Relevance 0
Recognition of a drug-induced HUS is necessary to avoid reexposure and recurrent HUS.
Positive_regulation (necessary) of HUS Binding (Recognition) of associated with hemolytic uremic syndrome
2) Confidence 0.39 Published 2007 Journal Clin. Nephrol. Section Abstract Doc Link 17915621 Disease Relevance 1.15 Pain Relevance 0.17
Binding of CFH to human cells is initially mediated by the C-terminal domains SCR19 and 20, which then leads to an uncoiling of the protein and exposure of other CFH domains to additional cell-surface receptors [13], [53]–[55].
Positive_regulation (mediated) of CFH Binding (Binding) of
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.09 Pain Relevance 0
Thus it appears that the host range for LB spirochetes is determined by their sensitivities to complement of particular host species [260], and furthermore, the ability to bind factor H and FHL-1 appears to depend on the genotype of LB spirochetes [123].
Spec (appears) Positive_regulation (depend) of factor H Binding (bind) of associated with lyme disease
4) Confidence 0.01 Published 2009 Journal Veterinary Research Section Body Doc Link PMC2701186 Disease Relevance 0.40 Pain Relevance 0

General Comments

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