INT14690

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Context Info
Confidence 0.80
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 124
Total Number 126
Disease Relevance 85.17
Pain Relevance 27.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 9
granulocyte 8
macrophage 7
blood 6
PGE2 5
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1082 100.00 Very High Very High Very High
Inflammation 899 100.00 Very High Very High Very High
Pain 242 100.00 Very High Very High Very High
chemokine 204 100.00 Very High Very High Very High
metalloproteinase 120 100.00 Very High Very High Very High
fibrosis 58 100.00 Very High Very High Very High
substance P 38 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
Enkephalin 10 99.98 Very High Very High Very High
cINOD 122 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1121 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 720 100.00 Very High Very High Very High
Sleep Disorders 87 100.00 Very High Very High Very High
Fibrosis 59 100.00 Very High Very High Very High
Nasal Polyps 1 100.00 Very High Very High Very High
Lymphatic System Cancer 125 99.96 Very High Very High Very High
Pulmonary Alveolar Proteinosis 13 99.96 Very High Very High Very High
Adrenal Cancer 2 99.96 Very High Very High Very High
Disease 1568 99.88 Very High Very High Very High
Neutrophil Disorders 7 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it was reported that granulocyte-macrophage colony stimulating factor (GM-CSF) secretion was also detected by human colorectal cancer specimens and cell lines [12,13].
Localization (secretion) of granulocyte-macrophage colony stimulating factor in macrophage associated with colon cancer
1) Confidence 0.80 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.19 Pain Relevance 0
GVAX immunotherapy for prostate cancer is comprised of two prostate tumor cell lines that have been modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF), an immune stimulatory cytokine that plays a key role in stimulating the bodyÂ’s immune response, and then irradiated for safety.
Localization (secrete) of granulocyte-macrophage colony-stimulating factor in body associated with prostate cancer and cytokine
2) Confidence 0.78 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895780 Disease Relevance 0.75 Pain Relevance 0.12
Variations of these models can also be invoked to explain the relationships of CSF to plasma VL noted in some of the subject groups in this study.
Localization (relationships) of CSF in plasma
3) Confidence 0.73 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.11 Pain Relevance 0.13
We examined the mobilization of blood monocytes (MO) with recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) with regard to the in vitro generation of MO-derived tumor-cytotoxic macrophages (MAC) for use in adoptive immunotherapy of cancer patients.
Spec (examined) Localization (mobilization) of granulocyte-macrophage colony-stimulating factor in granulocyte associated with cancer and immunotherapy of cancer
4) Confidence 0.71 Published 1997 Journal J. Immunother. Section Abstract Doc Link 9336743 Disease Relevance 0.55 Pain Relevance 0
RESULTS: The GM-CSF ligand localized primarily in the glandular epithelium and myometrium with only light stromal staining.
Localization (localized) of GM-CSF in epithelium
5) Confidence 0.70 Published 2002 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 11963838 Disease Relevance 0.08 Pain Relevance 0
As mentioned earlier, some CRCs have the ability to secrete active G-CSF.
Localization (secrete) of G-CSF
6) Confidence 0.70 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.01 Pain Relevance 0
Furthermore, it was reported that granulocyte-macrophage colony stimulating factor (GM-CSF) secretion was also detected by human colorectal cancer specimens and cell lines [12,13].
Localization (secretion) of GM-CSF in macrophage associated with colon cancer
7) Confidence 0.70 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.12 Pain Relevance 0
Likewise, fluticasone was the strongest steroid in inhibiting release of GM-CSF (IC25 8.4x10(-11) M), followed by budesonide (IC25 2x10(-9) M), beclomethasone dipropionate (IC25 13x10(-8) M), and nedocromil sodium (IC25 >10(-5) M).
Localization (release) of GM-CSF
8) Confidence 0.70 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.21 Pain Relevance 0.29
We investigated the effect of fluticasone propionate, budesonide, beclomethasone dipropionate and nedocromil sodium on the release of granulocyte/macrophage colony-stimulating factor (GM-CSF) and on eosinophil survival induced by secretions from cultured nasal epithelial cells.
Localization (release) of GM-CSF in eosinophil
9) Confidence 0.70 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.16 Pain Relevance 0.19
These drugs may exert part of their therapeutic effect by modulating GM-CSF release.
Localization (release) of GM-CSF
10) Confidence 0.70 Published 1997 Journal Eur. Respir. J. Section Abstract Doc Link 9230235 Disease Relevance 0.17 Pain Relevance 0.29
Effect of topical anti-inflammatory drugs on epithelial cell-induced eosinophil survival and GM-CSF secretion.
Localization (secretion) of GM-CSF in eosinophil associated with inflammation and cinod
11) Confidence 0.70 Published 1997 Journal Eur. Respir. J. Section Title Doc Link 9230235 Disease Relevance 0.20 Pain Relevance 0.23
Second, phosphodiesterase inhibitors 3-isobutyl-1-methylxanthine (IBMX) and Ro-201724 (both of which elevate cAMP levels) decreased GM-CSF release, in the presence of PGE2.
Localization (release) of GM-CSF in PGE2
12) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.11 Pain Relevance 0.89
We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF.
Localization (release) of GM-CSF in PGE2 associated with cytokine
13) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.15 Pain Relevance 0.80
NO-ASA is the exception, because it does not increase GM-CSF release, although at millimolar concentrations cell viability is reduced.
Localization (release) of GM-CSF associated with aspirin
14) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0 Pain Relevance 0.70
Unlike acetylsalicylic acid (ASA), NO-ASA reduces the levels of PGE2, without increasing GM-CSF release, although cell viability is reduced at the highest concentration (1 mM).
Localization (release) of GM-CSF in PGE2 associated with aspirin
15) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.15 Pain Relevance 0.90
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Localization (release) of GM-CSF associated with cinod
16) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15680249 Disease Relevance 0.19 Pain Relevance 0.93
The effects of NSAIDs and NO-NSAIDs on GM-CSF release were attributable to the PGE2 mediated cyclic (c) AMP pathway because PGE2 reversed the effects of COX blockade.
Localization (release) of GM-CSF in PGE2 associated with cinod
17) Confidence 0.69 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.14 Pain Relevance 0.93
rhG-CSF in healthy donors: mobilization of peripheral hemopoietic progenitors and effect on peripheral blood leukocytes.
Localization (mobilization) of rhG-CSF in leukocytes associated with pain
18) Confidence 0.69 Published 1996 Journal J Hematother Section Title Doc Link 8877714 Disease Relevance 0.17 Pain Relevance 0.18
In vitro ebastine inhibits anti-IgE-induced release of prostaglandins and leukotrienes by nasal polyp cells and cytokines, including granulocyte–macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor, and IL-8.
Localization (release) of granulocyte-macrophage colony-stimulating factor in nasal associated with necrosis, cancer, nasal polyps and cytokine
19) Confidence 0.68 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC3003605 Disease Relevance 0.92 Pain Relevance 0.22
Opioid and tachykinin neuropeptides, which were derived from two biological sources (intact, and released from their corresponding precursors by the action of human cerebrospinal fluid (CSF) neuropeptidases), were characterized in human CSF by using a combination of post-high-performance liquid chromatographic (HPLC) detection techniques.
Localization (released) of CSF in cerebrospinal fluid associated with neuropeptide and opioid
20) Confidence 0.68 Published 1990 Journal J. Chromatogr. Section Abstract Doc Link 2329143 Disease Relevance 0 Pain Relevance 0.50

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