INT146914

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.41
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
macrophages 2
monocytes 2
saliva 1
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 168 99.40 Very High Very High Very High
rheumatoid arthritis 76 95.00 High High
spinal inflammation 32 89.56 High High
Inflammation 151 89.16 High High
Inflammatory mediators 6 76.56 Quite High
chemokine 27 74.12 Quite High
Pain 3 73.32 Quite High
Inflammatory response 18 69.52 Quite High
glial activation 2 63.76 Quite High
Arthritis 128 49.28 Quite Low
Disease Link Frequency Relevance Heat
Burning Mouth Syndrome 6 99.12 Very High Very High Very High
Oral Lichen Planus 6 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 98.76 Very High Very High Very High
Dermatitis 56 97.44 Very High Very High Very High
Mycobacterial Infection 54 96.24 Very High Very High Very High
Osteoarthritis 36 95.28 Very High Very High Very High
Rheumatoid Arthritis 179 95.00 High High
Hepatitis C Virus Infection 189 93.28 High High
Nicotine Addiction 66 90.44 High High
Disease 61 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are also compatible with those from Henning et al who reported a significant reduction of TLR2 protein and mRNA, and unaltered TLR4 expression during the in vitro maturation of human monocytes to macrophages in Teflon wells [39].
Negative_regulation (reduction) of TLR2 in macrophages
1) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.08 Pain Relevance 0
In the current study, we found by flow cytometry and qRT-PCR that TLR2 was downregulated within 24 hours of monocyte culture and remained low throughout the seven-day differentiation period into macrophages.
Negative_regulation (downregulated) of TLR2 in macrophages
2) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.10 Pain Relevance 0
In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA.
Negative_regulation (decreased) of TLR-2 mRNA in saliva associated with oral lichen planus and burning mouth syndrome
3) Confidence 0.43 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17916440 Disease Relevance 1.15 Pain Relevance 0.07
An increased TLR2 surface expression on human monocytes in response to LPS-stimulation has been described previously [13], whereas on the transcriptional level divergent data have been reported showing either upregulation [14,15], or downregulation [16,17] of TLR2-mRNA depending on timing and dose of stimulation.
Negative_regulation (downregulation) of TLR2 in monocytes
4) Confidence 0.41 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.76 Pain Relevance 0.04
mix tended to decrease both TLR2 and
Negative_regulation (decrease) of TLR2
5) Confidence 0.34 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 0.93 Pain Relevance 0.40
TLR2 protein was suppressed by 19 ± 7% (P < 0.05) below the baseline at 4 h.
Negative_regulation (suppressed) of TLR2
6) Confidence 0.31 Published 2008 Journal Diabetes Care Section Abstract Doc Link PMC2518353 Disease Relevance 0.43 Pain Relevance 0.07
TLR2 protein was suppressed by 19 ± 7% below baseline at 4 h following insulin infusion (P < 0.05) when compared with baseline and to control subjects (Fig. 2), while TLR4 protein levels were reduced by only 8 ± 5% (P = NS).
Negative_regulation (suppressed) of TLR2
7) Confidence 0.31 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.08 Pain Relevance 0
Inhibition of either TLR2 or gC1qR by blocking antibodies or RNA silencing will be of interest.
Negative_regulation (Inhibition) of TLR2
8) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.52 Pain Relevance 0.07
CD14 was reduced from 10.6 ± 16.6% before treatment to 2.5 ± 2% after treatment (P = 0.011), TLR4 was reduced from 46.9 ± 32.7% to 11.7 ± 12.5% (P = 0.008) and TLR2 was reduced from 11.7 ± 19.4% to 1.8 ± 2.9% (P = 0.012).


Negative_regulation (reduced) of TLR2
9) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.26 Pain Relevance 0.17
The out-degree distribution gives rise to three protein hubs, namely IL6 and TLR2 and TLR4 (the number of hubs is reduced here due to the higher power-law exponent), with out-degree greater than 2.
Negative_regulation (reduced) of TLR2
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0 Pain Relevance 0.03
When primary human monocytes are treated with ATRA (all-trans retinoic acid), TLR 2 and CD14 are downregulated without any change in expression of TLR 1 and 4 [142].
Negative_regulation (downregulated) of TLR 2 in monocytes
11) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.85 Pain Relevance 0.34
Taken together, these studies suggest that there is a defect in TLR 2/9.
Negative_regulation (defect) of TLR 2
12) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.24 Pain Relevance 0.04

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