INT146915

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.70
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 2
epithelial cells 1
endometrium 1
saliva 1
T cells 1
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6 97.68 Very High Very High Very High
Inflammation 78 97.28 Very High Very High Very High
orphanin 7 95.72 Very High Very High Very High
rheumatoid arthritis 56 94.84 High High
spinal inflammation 31 89.36 High High
Central nervous system 5 82.36 Quite High
Opioid 1 75.04 Quite High
Pain 3 74.28 Quite High
Inflammatory response 14 58.48 Quite High
Arthritis 46 42.64 Quite Low
Disease Link Frequency Relevance Heat
Burning Mouth Syndrome 6 99.60 Very High Very High Very High
Oral Lichen Planus 6 99.44 Very High Very High Very High
Disease 176 97.88 Very High Very High Very High
INFLAMMATION 90 97.28 Very High Very High Very High
Rheumatoid Arthritis 56 94.84 High High
Low Back Pain 31 89.36 High High
Pain 3 74.28 Quite High
Infection 7 70.32 Quite High
Seronegative Spondarthritis 17 42.64 Quite Low
Necrosis 12 42.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that human CD14(+) monocytes expresses the mRNA for ORL1.
Transcription (expresses) of CD14 in monocytes
1) Confidence 0.67 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.19 Pain Relevance 0.77
In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA.
Transcription (levels) of CD14 in saliva associated with oral lichen planus and burning mouth syndrome
2) Confidence 0.50 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17916440 Disease Relevance 1.16 Pain Relevance 0.07
A recent study performed on bovine endometrial cells, co-localised TLR4 transcripts with CD14 mRNA and protein to stromal and epithelial cells [35].
Transcription (transcripts) of CD14 in epithelial cells
3) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.20 Pain Relevance 0.07
Low levels of CD14 were detected in most cultures but tended to decrease during passaging.


Transcription (detected) of CD14
4) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.21 Pain Relevance 0.11
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
Transcription (detected) of CD14 in endometrium
5) Confidence 0.33 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.19 Pain Relevance 0.06
CD4+CD28+ T cells did not produce perforin after co-incubation with LPS, even after addition of sCD14 or autologous serum (Figure 4a and data not shown).
Transcription (addition) of sCD14 in T cells
6) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.25 Pain Relevance 0.25
CD14 mRNA levels determined by real-time PCR were comparable between BD and healthy control individuals, indicating that there was no difference between groups in the proportion of monocytes among circulating leukocytes (data not shown).
Spec (determined) Transcription (levels) of CD14 in monocytes associated with disease
7) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.86 Pain Relevance 0
However, no significant differences in levels of mRNA expression for CD14 and MD-2, which are critically involved in LPS-mediated signal transduction of TLR, were found between patients and control individuals (data not shown).
Transcription (expression) of CD14
8) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.64 Pain Relevance 0.03

General Comments

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