INT146919

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.44
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnf, Ccl2) extracellular region (Tnf, Ccl2) aging (Ccl2)
intracellular (Tnf) extracellular matrix organization (Tnf) cytoplasm (Ccl2)
Anatomy Link Frequency
acinar cells 4
Tnf (Rattus norvegicus)
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 15 99.08 Very High Very High Very High
Chronic pancreatitis 6 96.00 Very High Very High Very High
fibrosis 3 88.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 15 99.08 Very High Very High Very High
Pancreatitis 6 96.00 Very High Very High Very High
Fibrosis 3 88.92 High High
Injury 3 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner.
TNF-alpha Positive_regulation (induced) of Gene_expression (synthesis) of MCP-1 in acinar cells
1) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 17916652 Disease Relevance 0.59 Pain Relevance 0.35
PGE(2) modulates the TNF-alpha-induced MCP-1 synthesis and secretion from acinar cells.
TNF-alpha Positive_regulation (induced) of Gene_expression (synthesis) of MCP-1 in acinar cells
2) Confidence 0.16 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17916652 Disease Relevance 0.30 Pain Relevance 0.16
Coincubation with PGE(2) enhanced the TNF-alpha-induced MCP-1 synthesis significantly.
TNF-alpha Positive_regulation (induced) of Gene_expression (synthesis) of MCP-1
3) Confidence 0.11 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17916652 Disease Relevance 0.56 Pain Relevance 0.33

General Comments

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