INT146933

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.22
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ephb6) plasma membrane (Ephb6)
Ephb6 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 97.88 Very High Very High Very High
Hippocampus 25 80.40 Quite High
Pain 12 63.52 Quite High
melanocortin 1 receptor 8 25.00 Low Low
Inflammation 2 25.00 Low Low
Catechol-O-methyltransferase 27 14.96 Low Low
antidepressant 10 10.72 Low Low
depression 15 9.28 Low Low
Dopamine 15 5.00 Very Low Very Low Very Low
gABA 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 214 99.68 Very High Very High Very High
Anxiety Disorder 148 99.48 Very High Very High Very High
Infection 6 91.04 High High
Appetite Loss 6 90.36 High High
Cancer 2 85.76 High High
Necrosis 2 85.28 High High
Toxicity 2 74.72 Quite High
Affective Disorder 4 68.44 Quite High
Pain 17 63.52 Quite High
INFLAMMATION 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
I also found that the sensitivity to the lethal effect of LPS dramatically increased in aged mice (age effect), both B6 and B6-A(y).
Positive_regulation (increased) of B6
1) Confidence 0.05 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.48 Pain Relevance 0
I also found that the sensitivity to the lethal effect of LPS dramatically increased in aged mice (age effect), both B6 and B6-A(y).
Positive_regulation (increased) of B6
2) Confidence 0.05 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.48 Pain Relevance 0
Alternatively, enhanced B6 freezing during the CS-only and CS-UCS test trials may be due to an independent influence.
Positive_regulation (enhanced) of B6
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.33 Pain Relevance 0
This enhanced B6 freezing response during CS-UCS conditioning may reflect a persistence of the effect that was evident on test trials 1-6.
Positive_regulation (enhanced) of B6
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.34 Pain Relevance 0
The enhanced B6 freezing response (relative to BALB mice) was not directly related to a difference in the ability to learn associations or to orient to distressed objects.
Positive_regulation (enhanced) of B6
5) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.34 Pain Relevance 0.06
Importantly, we also do not yet know whether the enhanced B6 freezing response occurs specifically to presentation of the CS, or whether it also depends on concurrent recognition of it's own spatial position relative to the appropriate (contextual) environment.
Spec (whether) Positive_regulation (enhanced) of B6
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.34 Pain Relevance 0
For example, while the longer freezing responses of B6 mice on trials 1-6 is mediated by the passive transfer of fear from objects to subject, enhanced B6 freezing on trials 7-10, by contrast, could reflect the combined influence of this effect and individual learning, or it could be attributable to a distinct process, such as social facilitation of individual learning.
Positive_regulation (enhanced) of B6 associated with anxiety disorder
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2633046 Disease Relevance 0.32 Pain Relevance 0
Diazepam significantly (p < 0.0001) increased TST immobility in both B6 (n = 5) and NZB mice (n = 7).Fig. 5Effect of GABRA3 agonist SB-205384 and GABAA agonist diazepam on TST and OFT behavior. a SB-205384 (2 mg/kg) significantly reduced TST immobility in B6 but not in NZB mice.
Positive_regulation (increased) of B6 associated with agonist
8) Confidence 0.02 Published 2010 Journal Mamm Genome Section Body Doc Link PMC2890984 Disease Relevance 0.32 Pain Relevance 0.18
The mRNA sequence data for the B6 and D2 strain is available at GenBank (GU324998 contains B6 3?
Positive_regulation (data) of B6 associated with sprains and strains
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.28 Pain Relevance 0.11

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