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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.97
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
nerve 1
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Brush evoked pain 3 96.92 Very High Very High Very High
Spinal cord 2 95.84 Very High Very High Very High
IPN 1 93.24 High High
Potency 4 92.08 High High
Inflammation 1 82.56 Quite High
Neuropathic pain 4 80.68 Quite High
Peripheral nerve injury 1 75.00 Quite High
Stimulus evoked pain 1 69.64 Quite High
Lasting pain 1 63.28 Quite High
allodynia 1 53.60 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 7 99.16 Very High Very High Very High
Neuropathic Pain 8 96.92 Very High Very High Very High
Myelodysplastic Syndromes 62 96.56 Very High Very High Very High
Inflammatory Pain 1 93.24 High High
Reticulocytosis 5 92.68 High High
Erythrocytosis 35 91.88 High High
INFLAMMATION 1 82.56 Quite High
Fever 3 81.16 Quite High
Colitis 1 80.36 Quite High
Cytomegalovirus Infection 1 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that other Src family kinases are not compensating for deficiency of Lyn, Hck, and Fgr, and argue that therapy directed at Src kinases will be ineffective in PV patients.
Negative_regulation (deficiency) of Lyn associated with myelodysplastic syndromes
1) Confidence 0.53 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.00 Pain Relevance 0
We found that mice lacking lyn (lyn(-/-)) exhibit a striking reduction in the levels of phospho-SFK-IR and tactile allodynia after nerve injury, without any change in basal mechanical sensitivity or inflammatory pain.
Negative_regulation (lacking) of lyn in nerve associated with brush evoked pain, nervous system injury and ipn
2) Confidence 0.42 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.38 Pain Relevance 0.90
These include upregulation of the ABCB1 or ABCG2 drug efflux pumps,58,63,64 downregulation of human organic cation transporter 1 (hOCT1) drug influx transporters,65,66 overexpression of Lyn, a Src-family kinase,67 and other Bcr-Abl-independent mechanisms.
Negative_regulation (downregulation) of Lyn
3) Confidence 0.15 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.59 Pain Relevance 0.05

General Comments

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