INT146940

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.76
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Fyn) mitochondrion (Fyn) plasma membrane (Fyn)
kinase activity (Fyn)
Anatomy Link Frequency
myeloid cells 1
microglial cells 1
Fyn (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 2 97.20 Very High Very High Very High
Inflammation 1 90.36 High High
Neuropathic pain 4 88.48 High High
Brush evoked pain 3 80.96 Quite High
Stimulus evoked pain 1 77.44 Quite High
Peripheral nerve injury 1 75.00 Quite High
IPN 1 73.60 Quite High
Lasting pain 1 71.08 Quite High
allodynia 1 40.72 Quite Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Erythrocytosis 70 90.92 High High
Nervous System Injury 7 90.64 High High
INFLAMMATION 1 90.36 High High
Neuropathic Pain 8 88.48 High High
Reticulocytosis 10 81.28 Quite High
Hypersensitivity 3 77.44 Quite High
Pain 2 76.76 Quite High
Stress 2 76.20 Quite High
Hematological Disease 8 74.20 Quite High
Inflammatory Pain 1 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spinally derived microglial cells, we identified Lyn as the predominant SFK among the five members (Src, Fyn, Yes, Lck, and Lyn) known to be expressed in the CNS.
Gene_expression (expressed) of Fyn in microglial cells
1) Confidence 0.52 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.31 Pain Relevance 0.83
There is a possibility that one or more of the other six vertebrate Src family kinases might compensate for lack of these three, particularly Fyn, Yes, and c-Src, which are expressed in myeloid cells.
Gene_expression (expressed) of Fyn in myeloid cells
2) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.76 Pain Relevance 0
However, there was no overexpression of Fyn, Yes, or c-Src in myeloerythroid cells from polycythemic recipients of JAK2 V617F-transduced Lyn?
Neg (no) Gene_expression (overexpression) of Fyn
3) Confidence 0.36 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.69 Pain Relevance 0

General Comments

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