INT146943

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.65
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Anatomy Link Frequency
plasma 1
myeloid cells 1
microglial cells 1
Src (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 39 99.90 Very High Very High Very High
opioid receptor 84 99.06 Very High Very High Very High
Spinal cord 4 97.20 Very High Very High Very High
Inflammation 14 90.56 High High
Neuropathic pain 4 88.68 High High
Brush evoked pain 3 80.96 Quite High
Stimulus evoked pain 1 77.64 Quite High
Peripheral nerve injury 1 75.00 Quite High
IPN 1 73.60 Quite High
Morphine 77 72.36 Quite High
Disease Link Frequency Relevance Heat
Erythrocytosis 105 98.38 Very High Very High Very High
Myelodysplastic Syndromes 188 97.14 Very High Very High Very High
Breast Cancer 50 96.36 Very High Very High Very High
Adenocarcinoma 63 95.76 Very High Very High Very High
Aging 11 94.24 High High
Leukemia 52 91.88 High High
Nervous System Injury 7 90.64 High High
INFLAMMATION 16 90.56 High High
Atherosclerosis 6 88.80 High High
Neuropathic Pain 8 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spinally derived microglial cells, we identified Lyn as the predominant SFK among the five members (Src, Fyn, Yes, Lck, and Lyn) known to be expressed in the CNS.
Gene_expression (expressed) of Src in microglial cells
1) Confidence 0.49 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.31 Pain Relevance 0.84
Although Src kinases are activated by JAK2 in erythroid cells upon Epo stimulation [28] and a Src inhibitor impaired Epo-independent maturation of PV erythroid progenitors [13], we demonstrated that polycythemia induced by JAK2 V617F was independent of Lyn, Hck, and Fgr, the three principal Src family kinases expressed in myeloerythroid cells.
Gene_expression (expressed) of Src associated with erythrocytosis and myelodysplastic syndromes
2) Confidence 0.43 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.17 Pain Relevance 0
There is a possibility, however, that MOR may regulate other events upstream of PKC and Src activation as well.
Gene_expression (activation) of Src associated with kinase c and opioid receptor
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.34 Pain Relevance 0.78
Other mechanisms of imatinib resistance may include: increased expression of Bcr-Abl through genomic amplification (Nicolini et al 2006), overexpression of Lyn or other Src-family tyrosine kinases (Donato et al 2003; Dai et al 2004), or overexpression of drug efflux proteins such as P-glycoprotein, which may decrease the intracellular concentration of imatinib in leukemic cells (Thomas et al 2004).
Gene_expression (overexpression) of Src
4) Confidence 0.31 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761189 Disease Relevance 0.06 Pain Relevance 0
There is a possibility that one or more of the other six vertebrate Src family kinases might compensate for lack of these three, particularly Fyn, Yes, and c-Src, which are expressed in myeloid cells.
Gene_expression (expressed) of Src in myeloid cells
5) Confidence 0.29 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.75 Pain Relevance 0
However, there was no overexpression of Fyn, Yes, or c-Src in myeloerythroid cells from polycythemic recipients of JAK2 V617F-transduced Lyn?
Neg (no) Gene_expression (overexpression) of Src
6) Confidence 0.29 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.69 Pain Relevance 0
The expressions of FAK, phospho-FAK, cSrc, phospho-Src, Arp2, F-actin, paxillin, phospho-paxillin at protein level were reduced with both MU-sh and MC-sh treatments in 5310 cells (Fig. 8B).
Gene_expression (expressions) of Src
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.36 Pain Relevance 0
recruits Src and leads to activation of the p85 subunit of PI3K [60] and the ERK cascade [61].
Gene_expression (recruits) of Src
8) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.13 Pain Relevance 0.03
EGFR expression combined with c-Src overexpression can initiate oncogenic transformation and marked migratory and invasive behavior in human breast cancer cells [23].
Gene_expression (overexpression) of Src associated with breast cancer
9) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 0.18 Pain Relevance 0
The plasma membrane expression of EGFR (p = 0.02) and MET receptor (p < 0.0001) and the cytoplasmic proteins ADAM9 (p < 0.001), SRC (p < 0.0001), PKB?
Gene_expression (expression) of SRC in plasma
10) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.59 Pain Relevance 0
The human Shc locus (Src homologous and collagen) encodes three proteins with relative molecular masses of 46K (p46Shc), 52K (p52Shc) and 66K (p66Shc).
Gene_expression (locus) of Src
11) Confidence 0.13 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.42 Pain Relevance 0
Bcr-Abl positive cells cultured in the continuous presence of imatinib show a reduced Bcr-Abl protein level and an increase of expression of Src kinases (Donato et al 2003).
Gene_expression (expression) of Src
12) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.50 Pain Relevance 0
Besides Abl, ON012380 showed inhibitory activity against PDGFR kinases and the Src family member Lyn.


Gene_expression (kinases) of Src
13) Confidence 0.10 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.14 Pain Relevance 0

General Comments

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