INT146945

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.81
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
C8-B4 3
peripheral nerve 1
microglia 1
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Neuropathic pain 42 98.78 Very High Very High Very High
Peripheral nerve injury 2 97.56 Very High Very High Very High
Inflammation 39 97.24 Very High Very High Very High
IPN 6 95.40 Very High Very High Very High
Lasting pain 12 95.24 Very High Very High Very High
Stimulus evoked pain 4 89.24 High High
allodynia 14 88.84 High High
Brush evoked pain 18 87.48 High High
Dorsal horn 4 87.12 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 79 98.78 Very High Very High Very High
INFLAMMATION 60 97.24 Very High Very High Very High
Nervous System Injury 26 97.12 Very High Very High Very High
Inflammatory Pain 6 95.40 Very High Very High Very High
Pain 37 95.24 Very High Very High Very High
Hypersensitivity 7 89.04 High High
Stress 5 70.12 Quite High
Parasitemia 8 49.12 Quite Low
Disease 70 42.32 Quite Low
Plasmodium Infection 34 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.
Positive_regulation (required) of Lyn in peripheral nerve associated with pain, nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.49 Published 2008 Journal Glia Section Title Doc Link 17918263 Disease Relevance 1.20 Pain Relevance 0.97
In contrast to the neuropathic pain model, neither the upregulation of P2X4R expression [7] nor activation of Lyn tyrosine kinase [13] has been demonstrated in spinal microglia following peripheral inflammation caused by CFA.
Neg (nor) Positive_regulation (activation) of Lyn tyrosine kinase in microglia associated with inflammation and neuropathic pain
2) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.49 Pain Relevance 1.03
The Lyn/Syk pathway appears to be uniquely activated in the innate response to Hz crystals, as opposed to other NLRP3-activating crystals such as MSU.
Positive_regulation (activated) of Lyn
3) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.07 Pain Relevance 0
Altogether, these results reveal that Lyn/Syk activation following Hz exposure initiates the PI3K and ERK signaling pathways and these pathways appear to regulate the production of mature IL-1?.
Positive_regulation (activation) of Lyn
4) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
engagement of this receptor complex leads to the initiation of complex signaling events leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52].
Positive_regulation (activation) of Lyn
5) Confidence 0.20 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07
Also diagnostic of the activated state, qualitative RT-PCR experiments showed increased mRNAs for TLR4 and Lyn tyrosine kinase after C8-B4 cell activation for >4 h (Fig. 1 C) (Tsuda et al., 2003; Tanga et al., 2004; Coull et al., 2005).


Positive_regulation (activation) of Lyn tyrosine kinase in C8-B4
6) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.04
We measured elevated levels of Lyn tyrosine kinase in activated C8-B4 cells.
Positive_regulation (elevated) of Lyn tyrosine kinase in C8-B4
7) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.11
Also diagnostic of the activated state, qualitative RT-PCR experiments showed increased mRNAs for TLR4 and Lyn tyrosine kinase after C8-B4 cell activation for >4 h (Fig. 1 C) (Tsuda et al., 2003; Tanga et al., 2004; Coull et al., 2005).


Positive_regulation (increased) of Lyn tyrosine kinase in C8-B4
8) Confidence 0.17 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.04

General Comments

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