INT146946

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 8.90
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyn) Golgi apparatus (Lyn) plasma membrane (Lyn)
nucleus (Lyn) enzyme binding (Lyn) kinase activity (Lyn)
Anatomy Link Frequency
nerve 2
erythrocyte 1
spinal cord 1
C8-B4 1
eosinophil 1
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.68 Very High Very High Very High
Brush evoked pain 12 97.12 Very High Very High Very High
adenocard 1 95.28 Very High Very High Very High
IPN 4 93.44 High High
Potency 33 92.08 High High
Inflammatory mediators 4 90.92 High High
Inflammation 39 89.60 High High
Neuropathic pain 43 87.72 High High
Stimulus evoked pain 4 76.68 Quite High
Peripheral nerve injury 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Plasmodium Infection 34 100.00 Very High Very High Very High
Erythrocytosis 35 99.16 Very High Very High Very High
Nervous System Injury 28 99.16 Very High Very High Very High
Death 31 98.56 Very High Very High Very High
Myelodysplastic Syndromes 70 97.92 Very High Very High Very High
Neuropathic Pain 65 97.12 Very High Very High Very High
Inflammatory Pain 4 93.44 High High
INFLAMMATION 50 90.92 High High
Cancer 36 85.12 High High
Leukemia 86 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spinally derived microglial cells, we identified Lyn as the predominant SFK among the five members (Src, Fyn, Yes, Lck, and Lyn) known to be expressed in the CNS.
Gene_expression (expressed) of Lyn in microglial cells
1) Confidence 0.76 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.30 Pain Relevance 0.83
Lyn expression in the spinal cord was highly restricted to microglia, and its level was increased after nerve injury.
Gene_expression (expression) of Lyn in spinal cord associated with nervous system injury and spinal cord
2) Confidence 0.76 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.30 Pain Relevance 0.83
We found that mice lacking lyn (lyn(-/-)) exhibit a striking reduction in the levels of phospho-SFK-IR and tactile allodynia after nerve injury, without any change in basal mechanical sensitivity or inflammatory pain.
Neg (lacking) Gene_expression (lacking) of lyn in nerve associated with brush evoked pain, nervous system injury and ipn
3) Confidence 0.66 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.38 Pain Relevance 0.90
We found that mice lacking lyn (lyn(-/-)) exhibit a striking reduction in the levels of phospho-SFK-IR and tactile allodynia after nerve injury, without any change in basal mechanical sensitivity or inflammatory pain.
Neg (lacking) Gene_expression (lacking) of lyn in nerve associated with brush evoked pain, nervous system injury and ipn
4) Confidence 0.66 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.38 Pain Relevance 0.90
Although Src kinases are activated by JAK2 in erythroid cells upon Epo stimulation [28] and a Src inhibitor impaired Epo-independent maturation of PV erythroid progenitors [13], we demonstrated that polycythemia induced by JAK2 V617F was independent of Lyn, Hck, and Fgr, the three principal Src family kinases expressed in myeloerythroid cells.
Gene_expression (expressed) of Lyn associated with erythrocytosis and myelodysplastic syndromes
5) Confidence 0.54 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.19 Pain Relevance 0
Other mechanisms of imatinib resistance may include: increased expression of Bcr-Abl through genomic amplification (Nicolini et al 2006), overexpression of Lyn or other Src-family tyrosine kinases (Donato et al 2003; Dai et al 2004), or overexpression of drug efflux proteins such as P-glycoprotein, which may decrease the intracellular concentration of imatinib in leukemic cells (Thomas et al 2004).
Gene_expression (overexpression) of Lyn
6) Confidence 0.46 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761189 Disease Relevance 0.06 Pain Relevance 0
Several mechanisms may contribute to imatinib resistance, including increased expression of BCR-ABL kinase through gene amplification, decreased intracellular drug concentrations caused by drug efflux proteins (OCT1), clonal evolution, or over-expression of Src kinases (Lyn, Hck) involved in BCR-ABL independent activation of alternative pathways (Apperley 2007).
Gene_expression (over) of Lyn
7) Confidence 0.41 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.08 Pain Relevance 0
Several mechanisms may contribute to imatinib resistance, including increased expression of BCR-ABL kinase through gene amplification, decreased intracellular drug concentrations caused by drug efflux proteins (OCT1), clonal evolution, or over-expression of Src kinases (Lyn, Hck) involved in BCR-ABL independent activation of alternative pathways (Apperley 2007).
Gene_expression (expression) of Lyn
8) Confidence 0.32 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.08 Pain Relevance 0
Altogether, these results reveal that Lyn/Syk activation following Hz exposure initiates the PI3K and ERK signaling pathways and these pathways appear to regulate the production of mature IL-1?.
Gene_expression (exposure) of Lyn
9) Confidence 0.32 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Qualitative reverse transcription (RT)-PCR analysis of TLR4 and Lyn tyrosine kinase transcript expression
Gene_expression (expression) of Lyn tyrosine kinase
10) Confidence 0.28 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
We measured elevated levels of Lyn tyrosine kinase in activated C8-B4 cells.
Gene_expression (levels) of Lyn tyrosine kinase in C8-B4
11) Confidence 0.28 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.11
Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis.

Gene_expression (produces) of Lyn in erythrocyte associated with plasmodium infection
12) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Title Doc Link PMC2722371 Disease Relevance 0.48 Pain Relevance 0.09
These include upregulation of the ABCB1 or ABCG2 drug efflux pumps,58,63,64 downregulation of human organic cation transporter 1 (hOCT1) drug influx transporters,65,66 overexpression of Lyn, a Src-family kinase,67 and other Bcr-Abl-independent mechanisms.
Gene_expression (overexpression) of Lyn
13) Confidence 0.28 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.52 Pain Relevance 0.05
The role of Src kinases for imatinib resistance has been further supported by the finding that siRNA-mediated inhibition of Lyn expression significantly reduced proliferation and survival of imatinib resistant Bcr-Abl positive cells (Ptasznik et al 2004).
Gene_expression (expression) of Lyn
14) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.41 Pain Relevance 0
Copy number for each molecule (all P2X subunits and Lyn tyrosine kinase) was determined based on comparisons to standard curves, and for each sample, the copy number for each molecule was normalized to the expression of the endogenous housekeeping gene hypoxanthine phosphoribosyl transferase (HPRT).


Gene_expression (expression) of Lyn tyrosine kinase
15) Confidence 0.25 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0
Besides Abl, ON012380 showed inhibitory activity against PDGFR kinases and the Src family member Lyn.


Gene_expression (kinases) of Lyn
16) Confidence 0.23 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.14 Pain Relevance 0
Ligation of Fas by agonistic antibody has been shown to result in tyrosine phosphorylation of several intracellular proteins and tyrosine kinase inhibitors lavendustin A and genistein have been reported to block Fas-receptor-induced cell death.109 Lyn phosphorylation by Fas has been reported, and decreases in the expression of Lyn by antisense technique resulted in partial reversal of Fas-induced cell death.109 Similarly, nitric oxide and cyclic adenosine 3':5'-monophosphate (cAMP) and cGMP have been reported to reverse Fas-induced eosinophil death.128 Fas-ligation induces caspase-3 and -8 activation and loss of mitochondrial membrane potential (??
Gene_expression (expression) of Lyn in eosinophil associated with adenocard and death
17) Confidence 0.16 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.61 Pain Relevance 0.05

General Comments

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