INT146948

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.23
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
spinal nerve 2
spinal cord 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
intrathecal 3 99.84 Very High Very High Very High
IPN 1 98.44 Very High Very High Very High
Brush evoked pain 5 97.36 Very High Very High Very High
Neuropathic pain 8 79.44 Quite High
allodynia 2 78.16 Quite High
Peripheral nerve injury 1 75.00 Quite High
Inflammation 1 73.12 Quite High
Stimulus evoked pain 1 60.20 Quite High
Lasting pain 1 53.84 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 13 100.00 Very High Very High Very High
Inflammatory Pain 1 98.44 Very High Very High Very High
Neuropathic Pain 15 97.36 Very High Very High Very High
INFLAMMATION 1 73.12 Quite High
Hypersensitivity 1 60.20 Quite High
Pain 2 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vivo studies, the upregulation of P2X(4)Rs in the spinal cord after spinal nerve injury was significantly suppressed by intrathecal administration of echistatin.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of P2X in spinal nerve associated with nervous system injury, intrathecal and spinal cord
1) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.87 Pain Relevance 0.77
Importantly, lyn(-/-) mice displayed impaired upregulation of the ionotropic ATP receptor subtype P2X(4) receptors (P2X(4)R) in the spinal cord after nerve injury, which is crucial for tactile allodynia.
Negative_regulation (impaired) of Positive_regulation (upregulation) of P2X in spinal cord associated with brush evoked pain, nervous system injury and spinal cord
2) Confidence 0.24 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.36 Pain Relevance 0.98

General Comments

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