INT146964

Context Info Confidence 0.12 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.30 Pain Relevance 0.31

nucleus (TCF19, Nfkb1) mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1) cytoplasm (Nfkb1) cell proliferation (TCF19)

TCF19 (Homo sapiens) Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 2 77.28 Inflammation 3 75.00 Spinal cord 2 75.00 Inflammatory response 1 70.20 Hyperalgesia 1 67.84 GABAergic 1 61.04 COX2 3 25.00

Disease Link Frequency Relevance Heat Frailty 12 100.00 INFLAMMATION 2 75.00 Hypersensitivity 1 74.00 Hyperalgesia 1 67.84 Nociception 1 67.16 Injury 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Decoys targeting the p65/p50 binding site on the COX-2 promoter decreased SCI-induced cell losses, NF-kappaB p65/p50 DNA-binding activity, and COX-2 and iNOS protein levels.

Negative_regulation (decreased) of SCI Negative_regulation (losses) of NF-kappaB associated with frailty

1) Confidence 0.12 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 17918744 Disease Relevance 1.30 Pain Relevance 0.31

General Comments

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