INT146991

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 20.76
Pain Relevance 8.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
lung 6
small intestine 4
spinal 4
adipose tissue 4
dendritic cells 3
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 9 99.92 Very High Very High Very High
Arthritis 6 99.66 Very High Very High Very High
Neuropathic pain 123 99.62 Very High Very High Very High
Cancer pain 294 99.48 Very High Very High Very High
Eae 148 99.48 Very High Very High Very High
cytokine 309 99.42 Very High Very High Very High
Lasting pain 24 99.00 Very High Very High Very High
Inflammation 311 98.12 Very High Very High Very High
Pain 123 97.52 Very High Very High Very High
Inflammatory mediators 21 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 220 99.84 Very High Very High Very High
Arthritis 33 99.84 Very High Very High Very High
Bone Cancer 324 99.68 Very High Very High Very High
Neuropathic Pain 250 99.62 Very High Very High Very High
Stress 225 99.62 Very High Very High Very High
Injury 166 99.48 Very High Very High Very High
Sepsis 315 99.08 Very High Very High Very High
Pain 207 99.00 Very High Very High Very High
Insulin Resistance 100 98.44 Very High Very High Very High
INFLAMMATION 385 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR4 expression increases in the bone cancer pain model
Positive_regulation (increases) of Gene_expression (expression) of TLR4 associated with cancer pain and bone cancer
1) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.22 Pain Relevance 0.58
In a model of neuropathic pain, spinal microglia TLR4 mRNA expression is also increased after L5 nerve transection in rats [24].
Positive_regulation (increased) of Gene_expression (expression) of TLR4 mRNA in nerve associated with neuropathic pain
2) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.58 Pain Relevance 0.90
Our data showed that the spinal microglial activation markers mRNA, TLR4 mRNA and TLR4 protein expression were significantly elevated in the rat model of bone cancer pain.
Positive_regulation (elevated) of Gene_expression (expression) of TLR4 in spinal associated with cancer pain and bone cancer
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.75 Pain Relevance 1.09
These phenomena may be accounted for by the upregulation of iNOS/NO through the increased expression of TLR4 in the small intestine of arthritic rats.
Positive_regulation (increased) of Gene_expression (expression) of TLR4 in small intestine associated with arthritis
4) Confidence 0.68 Published 2007 Journal Life Sci. Section Abstract Doc Link 17920637 Disease Relevance 0.72 Pain Relevance 0.14
Increased susceptibility of small intestine to NSAID-provoked ulceration in rats with adjuvant-induced arthritis: involvement of enhanced expression of TLR4.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR4 in small intestine associated with cinod and arthritis
5) Confidence 0.68 Published 2007 Journal Life Sci. Section Title Doc Link 17920637 Disease Relevance 0.61 Pain Relevance 0.39
The endotoxemia that occurs after strenuous exercise results in increased circulating LPS and may be another mechanism underlying the elevation in TLR-4 and NF-kBp65 protein expression [21].
Positive_regulation (elevation) of Gene_expression (expression) of TLR-4 associated with endotoxemia
6) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.50 Pain Relevance 0.12
Taken together, our results suggest that the increase in cytokine concentration and augmented TLR-4 and NF-kBp65 protein expression induced by overtraining in the epidydymal adipose tissue may lead to a shift toward increased inflammation.
Positive_regulation (induced) of Gene_expression (expression) of TLR-4 in adipose tissue associated with inflammation, obesity and cytokine
7) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.78 Pain Relevance 0.18
To construct a green fluorescent protein (GFP) tagged TLR4 expressing vector, total RNA was extracted from rat lung tissues using Tri-Reagent (TaKaRa, Japan).
Positive_regulation (tagged) of Gene_expression (expressing) of TLR4 in lung
8) Confidence 0.50 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0 Pain Relevance 0
To construct a green fluorescent protein (GFP) tagged TLR4 expressing vector, total RNA was extracted from rat lung tissues using Tri-Reagent (TaKaRa, Japan).
Positive_regulation (tagged) of Gene_expression (expressing) of TLR4 in lung
9) Confidence 0.50 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0.22 Pain Relevance 0.23
Our data showed that the spinal microglial activation markers mRNA, TLR4 mRNA and TLR4 protein expression were significantly elevated in the rat model of bone cancer pain.
Positive_regulation (elevated) of Gene_expression (expression) of TLR4 mRNA in spinal associated with cancer pain and bone cancer
10) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 1.76 Pain Relevance 1.10
In a rat model of complete Freund's adjuvant-induced chronic pain, increased microglial activation, accompanied by upregulation of TLR4 mRNA expression and release of TNFa, IL-1?
Positive_regulation (upregulation) of Gene_expression (expression) of TLR4 mRNA associated with lasting pain
11) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.98 Pain Relevance 1.01
The expression of iNOS and TLR4 in the intestine was enhanced in arthritic rats as compared with normal rats.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR4 in intestine associated with arthritis
12) Confidence 0.49 Published 2007 Journal Life Sci. Section Abstract Doc Link 17920637 Disease Relevance 0.81 Pain Relevance 0.26
Real time RT-PCR showed a significant up-regulation of TLR4 mRNA expression 1 day after CCI compared to the sham group (P=0.0000).
Positive_regulation (regulation) of Gene_expression (expression) of TLR4 mRNA associated with eae
13) Confidence 0.47 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0.35 Pain Relevance 0.24
Real time RT-PCR showed a significant up-regulation of TLR4 mRNA expression 1 day after CCI compared to the sham group (P=0.0000).
Positive_regulation (up) of Gene_expression (expression) of TLR4 mRNA associated with eae
14) Confidence 0.47 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 0.35 Pain Relevance 0.24
These data suggest that TLR4 expression was significantly up-regulated in the bone cancer pain model caused by Walker 256 cells inoculation.


Positive_regulation (up-regulated) of Gene_expression (expression) of TLR4 associated with cancer pain and bone cancer
15) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.85 Pain Relevance 0.51
Few studies have investigated the impact of chronic stress on TLR expression and function, however of those that have done so, repeated social defeat stress has been shown to increase the expression of TLR2 and TLR4 [19] and increase TLR-mediated release of pro-inflammatory cytokines from splenic monocytes and dendritic cells [20].
Positive_regulation (increase) of Gene_expression (expression) of TLR4 in dendritic cells associated with stress, inflammation and cytokine
16) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.99 Pain Relevance 0.31
They found that MV of healthy mice resulted in increased expression of endogenous TLR4 ligands in the bronchoalveolar lavage fluid and enhanced TLR4 lung gene expression in lung homogenates that was associated with increased levels of TNF-?
Positive_regulation (enhanced) of Gene_expression (expression) of TLR4 in lung
17) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.38 Pain Relevance 0.11
We and others have previously demonstrated that TLR4 signaling is activated in diet induced obesity (DIO), and that this activation culminates in an increase in the activation of downstream effectors such as IKK?
Positive_regulation (activated) of Gene_expression (signaling) of TLR4 associated with obesity
18) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.02 Pain Relevance 0.11
In septic animals, there was an increase in TLR4 activation and also in downstream effectors that may have an important role in the insulin resistance of these animals [50].
Positive_regulation (increase) of Gene_expression (activation) of TLR4 associated with insulin resistance
19) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.84 Pain Relevance 0.11
Overall, our data demonstrate that atorvastatin exerts direct regulatory effects on TLR4 expression/activation in an animal model of sepsis that influences TLR4 signaling.
Positive_regulation (activation) of Gene_expression (expression) of TLR4 associated with sepsis
20) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.15 Pain Relevance 0.07

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