INT147028

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Context Info
Confidence 0.14
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.06
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
neurons 1
masseter 1
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 232 100.00 Very High Very High Very High
spinal dorsal horn 6 99.74 Very High Very High Very High
trigeminal ganglion 48 93.36 High High
IPN 1 90.00 High High
Pain 23 85.24 High High
addiction 9 78.40 Quite High
nociceptor 35 77.44 Quite High
Lasting pain 1 75.56 Quite High
central sensitization 3 75.52 Quite High
Stimulus evoked pain 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Acidosis 150 93.92 High High
Ganglion Cysts 66 93.72 High High
Hypersensitivity 3 93.24 High High
Inflammatory Pain 2 90.00 High High
Pain 15 85.24 High High
Hypoxia 62 83.12 Quite High
Nociception 48 68.40 Quite High
Cv Unclassified Under Development 36 68.20 Quite High
Hyperalgesia 2 35.92 Quite Low
Epilepsy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of the hyperaemic response to luminal CO(2) by CA, TRPV1 and ASIC inhibitors implicates CA and these chemosensors in transduction of the luminal acid signal.
Negative_regulation (inhibitors) of ASIC
1) Confidence 0.14 Published 2008 Journal Gut Section Body Doc Link 18682519 Disease Relevance 0 Pain Relevance 0
However, in the absence of selective blockers of ASIC subunits, we cannot definitively assign the currents we observed to specific ASIC subunits or combinations of subunits.
Negative_regulation (blockers) of ASIC associated with asic
2) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.35 Pain Relevance 0.54
The ASIC channels in trigeminal masseter afferents seemed to be largely comprised of homomeric ASIC3 channels or ASIC channel heteromers containing ASIC3.
Negative_regulation (comprised) of ASIC in masseter associated with asic
3) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.18 Pain Relevance 0.69
16 s) from desensitization, reminiscent of the prolonged recovery property of heterologously expressed ASIC1a homomers (?
Negative_regulation (reminiscent) of ASIC1a
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.50
Second, the ASIC current is largely (>75%) blocked by PcTX1, a specific blocker for ASIC1a homomers [34], [35].
Negative_regulation (blocker) of ASIC1a associated with asic
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.50
Here, we identify the Ca2+-permeable, homomeric ASIC1a channels as the predominant ASICs in rat SDH neurons and downregulation of ASIC1a by local rat spinal infusion with specific inhibitors or antisense oligonucleotides markedly attenuated complete Freund's adjuvant (CFA)-induced thermal and mechanical hypersensitivity.
Negative_regulation (downregulation) of ASIC1a in neurons associated with spinal dorsal horn, hypersensitivity and asic
6) Confidence 0.13 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.69 Pain Relevance 1.13
Second, the ASIC current is largely (>75%) blocked by PcTX1, a specific blocker for ASIC1a homomers [34], [35].
Negative_regulation (blocked) of ASIC associated with asic
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.51
One possible explanation for this is that oxygen and glucose deprivation has recently been reported to both increase the amplitude and slow the inactivation of ASIC1a currents in mouse hippocampal neurones [26].
Negative_regulation (inactivation) of ASIC1a
8) Confidence 0.01 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.84 Pain Relevance 0.04

General Comments

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