INT147029

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
SDH 1
Accn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 59 100.00 Very High Very High Very High
spinal dorsal horn 6 100.00 Very High Very High Very High
IPN 1 99.48 Very High Very High Very High
Pain 6 98.98 Very High Very High Very High
nociceptor 1 90.16 High High
Lasting pain 1 88.28 High High
Stimulus evoked pain 1 75.00 Quite High
Dorsal horn neuron 1 75.00 Quite High
tolerance 7 72.16 Quite High
ischemia 54 71.76 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.48 Very High Very High Very High
Pain 4 98.98 Very High Very High Very High
Hypersensitivity 3 75.00 Quite High
Cv Unclassified Under Development 52 71.76 Quite High
Death 9 71.24 Quite High
Acidosis 10 65.60 Quite High
Brain Hemorrhage 3 60.96 Quite High
Nociception 2 57.20 Quite High
Increased Venous Pressure Under Development 1 35.16 Quite Low
Myocardial Infarction 1 33.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most recently cloned subunit, ASIC 4, is not activated by any known ligand and may thus also play a modulatory role [21].
Neg (not) Positive_regulation (activated) of ASIC 4 associated with asic
1) Confidence 0.19 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.76 Pain Relevance 0.84
Previous pharmacological and behavioral studies suggest that peripheral acid-sensing ion channels (ASICs) contribute to pain sensation, and the expression of ASIC subunits is elevated in the rat spinal dorsal horn (SDH) in an inflammatory pain model.
Positive_regulation (elevated) of spinal dorsal horn in SDH associated with pain, ipn, spinal dorsal horn and asic
2) Confidence 0.05 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.50 Pain Relevance 0.88

General Comments

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