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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.44
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
neurons 2
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 116 100.00 Very High Very High Very High
ischemia 62 99.98 Very High Very High Very High
central sensitization 3 99.28 Very High Very High Very High
c fibre 1 98.36 Very High Very High Very High
spinal dorsal horn 6 95.88 Very High Very High Very High
Pain 6 83.20 Quite High
IPN 1 78.96 Quite High
Antinociceptive 1 75.44 Quite High
Stimulus evoked pain 1 75.00 Quite High
Dorsal horn neuron 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 58 99.98 Very High Very High Very High
Hypersensitivity 3 97.32 Very High Very High Very High
Nociception 2 95.72 Very High Very High Very High
Pain 4 83.20 Quite High
Inflammatory Pain 2 78.96 Quite High
Apoptosis 5 74.76 Quite High
Death 9 53.48 Quite High
Brain Hemorrhage 4 50.00 Quite Low
Acidosis 13 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, in vivo electrophysiological recording showed that the elevated ASIC1a activity is required for two forms of central sensitization: C-fiber-induced "wind-up" and CFA-induced hypersensitivity of SDH nociceptive neurons.
Positive_regulation (required) of Positive_regulation (elevated) of ASIC1a in neurons associated with nociception, c fibre, central sensitization, spinal dorsal horn and hypersensitivity
1) Confidence 0.21 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.74 Pain Relevance 1.23
We thus examined whether activation of ASIC channels leads to [Ca2+]i elevation in NG2 cells (Fig. 5A).
Spec (whether) Positive_regulation (elevation) of Spec (whether) Positive_regulation (activation) of ASIC associated with asic
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.18
We found that global ischemia induced a marked increase in ASIC 2a mRNA within three hours of ischemia.
Positive_regulation (induced) of Positive_regulation (increase) of ASIC associated with ischemia and asic
3) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.70 Pain Relevance 0.52

General Comments

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