INT147088

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.86
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HHEX) cell proliferation (HHEX) signal transduction (HHEX)
nucleus (HHEX) cell cycle (HHEX) transcription factor binding (HHEX)
Anatomy Link Frequency
fat 3
hepatocyte 1
HHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 5 100.00 Very High Very High Very High
Central nervous system 21 99.68 Very High Very High Very High
potassium channel 4 86.90 High High
Pain 16 81.88 Quite High
IPN 3 66.52 Quite High
Opioid 3 65.00 Quite High
Neuropathic pain 2 62.88 Quite High
Inflammation 13 62.04 Quite High
Spinal cord 4 59.20 Quite High
Dorsal horn 2 58.56 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 191 100.00 Very High Very High Very High
Obesity 111 100.00 Very High Very High Very High
Exostoses 2 100.00 Very High Very High Very High
Disease 40 99.32 Very High Very High Very High
Lysosome Storage Disease 8 97.88 Very High Very High Very High
Disease Progression 2 96.76 Very High Very High Very High
Lysosomal Storage Diseases 4 91.12 High High
Apoptosis 31 90.80 High High
Thyroid Neoplasm 1 89.64 High High
Oxidative Phosphorylation Disease 1 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIMS/HYPOTHESIS: Recently, several groups have carried out whole-genome association studies in European and European-origin populations and found novel type 2 diabetes-susceptibility genes, fat mass and obesity associated (FTO), solute carrier family 30 (zinc transporter), member 8 (SLC30A8), haematopoietically expressed homeobox (HHEX), exostoses (multiple) 2 (EXT2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2), which had not been in the list of functional candidates.
Gene_expression (found) of HHEX in fat associated with diabetes mellitus, member 8, obesity and exostoses
1) Confidence 0.65 Published 2007 Journal Diabetologia Section Abstract Doc Link 17928989 Disease Relevance 0.38 Pain Relevance 0.10
AIMS/HYPOTHESIS: Recently, several groups have carried out whole-genome association studies in European and European-origin populations and found novel type 2 diabetes-susceptibility genes, fat mass and obesity associated (FTO), solute carrier family 30 (zinc transporter), member 8 (SLC30A8), haematopoietically expressed homeobox (HHEX), exostoses (multiple) 2 (EXT2), CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B) and insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2), which had not been in the list of functional candidates.
Gene_expression (expressed) of HHEX in fat associated with diabetes mellitus, member 8, obesity and exostoses
2) Confidence 0.65 Published 2007 Journal Diabetologia Section Abstract Doc Link 17928989 Disease Relevance 0.37 Pain Relevance 0.10
There was no significant association of the KCNJ11 SNP rs5219, the CDKAL1 SNP rs10946398, the SLC30A8 SNP rs13266634, the HHEX SNP rs1111875, or the FTO SNP rs9939609 with T2D.
Gene_expression (rs1111875) of HHEX associated with diabetes mellitus
3) Confidence 0.60 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 1.14 Pain Relevance 0
The variants selected were the potassium inwardly-rectifying channel J11 (KCNJ11) single nucleotide polymorphism (SNP) rs5219 (E23K variant); the peroxisome proliferator-activated receptor gamma (PPARG) SNP rs1801282 (Pro12Ala variant); the transcription factor 7-like 2 (TCF7L2) SNP rs7903146; the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) SNP rs4402960; the CDK5 regulatory subunit associated protein1-like 1 (CDKAL1) SNP rs10946398; the solute carrier family 30 (zinc transporter), member 8 (SLC30A8) SNP rs13266634; the hematopoietically expressed homeobox (HHEX) SNP rs1111875; and the fat mass and obesity associated (FTO) SNP rs9939609.
Gene_expression (expressed) of HHEX in fat associated with member 8 and obesity
4) Confidence 0.54 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.58 Pain Relevance 0.10
There are now at least 20 loci containing genes that increase the risk of T2D, including potassium channels (KCNJ11 [potassium inwardly-rectifying channel, subfamily J, member 11] and KCNQ1 [potassium voltage-gated channel, KQT-like subfamily, member 1]) [19], cell cycle regulators (CDKAL1 [regulatory subunit associated protein 1-like 1], CDKN2A-2B [cyclin-dependent kinase inhibitor 2A-2B], and CDC123-CAMK1D [cell division cycle 123 homolog- calcium/calmodulin-dependent protein kinase ID]) [20], nuclear hormone receptor (PPARG [peroxisome proliferator-activated receptor gamma]) [21], melatonin receptor (MTNR1B [melatonin receptor 1B]) [22], transcription factors (TCF7L2 [transcription factor 7-like 2], TCF2 or HNF1B [hepatocyte nuclear factor 1 beta], HHEX [hematopoietically expressed homeobox], and JAZF1 [JAZF zinc finger 1]) [23], translational regulator (IGF2BP2 [insulin-like growth factor 2 mRNA binding protein 2]) [24], zinc transporter (SLC30A8 [solute carrier family 30 zinc transporter member 8]) [25], apoptosis components (THADA [thyroid adenoma associated]) [26], metalloprotease (ADAMTS9 [ADAM metallopeptidase with thrombospondin type 1 motif, 9]) [27], calcium homeostasis component (WFS1 [Wolfram syndrome 1 homolog]) [28], fat mass and obesity-associated gene (FTO [fat mass and obesity associated]) [29], pancreas organogenesis (NOTCH2 [Notch homolog 2]) [30], and surface glycoprotein (TSPAN8 [tetraspanin-8]) [31].
Gene_expression (expressed) of HHEX in hepatocyte associated with oxidative phosphorylation disease, thyroid neoplasm, diabetes mellitus, member 8, obesity, potassium channel and apoptosis
5) Confidence 0.31 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901187 Disease Relevance 0.75 Pain Relevance 0.13
Therapy of lysosomal storage disorders with neurological involvement, such as Tay-Sachs (TS) disease, requires active hexosaminidase (Hex) A production in the CNS and an efficient therapeutic approach that can act faster than human disease progression.
Gene_expression (production) of Hex associated with central nervous system, disease, disease progression and lysosome storage disease
6) Confidence 0.17 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.64 Pain Relevance 0.56

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