INT147108

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.01
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TGFB1, FN1) extracellular region (TGFB1, FN1) proteinaceous extracellular matrix (TGFB1, FN1)
aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
Anatomy Link Frequency
nerve 4
fibroblasts 2
TGFB1 (Homo sapiens)
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 99.98 Very High Very High Very High
Nerve growth factor 12 99.80 Very High Very High Very High
metalloproteinase 3 99.08 Very High Very High Very High
dexamethasone 16 98.40 Very High Very High Very High
chemokine 3 81.56 Quite High
Endocannabinoid 24 78.80 Quite High
antagonist 23 71.56 Quite High
Pain 6 65.76 Quite High
Cannabinoid receptor 18 53.20 Quite High
Cannabinoid 26 50.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 4 89.88 High High
Adhesions 3 82.72 Quite High
Primary Sclerosing Cholangitis 44 79.44 Quite High
Apoptosis 11 75.24 Quite High
Death 2 65.44 Quite High
Necrosis 3 54.40 Quite High
INFLAMMATION 14 50.00 Quite Low
Fibrosis 11 50.00 Quite Low
Pancreatitis 32 35.92 Quite Low
Cirrhosis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
TGF-beta1 Positive_regulation (increased) of Gene_expression (synthesis) of fibronectin in nerve associated with nerve growth factor and dexamethasone
1) Confidence 0.47 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.17 Pain Relevance 0.68
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
TGF-beta1 Positive_regulation (increased) of Gene_expression (expression) of fibronectin in nerve associated with nerve growth factor and dexamethasone
2) Confidence 0.31 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.17 Pain Relevance 0.68
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
TGFbeta Positive_regulation (stimulates) of Gene_expression (synthesis) of fibronectin associated with metalloproteinase and cytokine
3) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.59 Pain Relevance 0.28
RESULTS: TGF-beta1 significantly stimulated alpha-SMA, collagen I and fibronectin production in peritoneal fibroblasts.
TGF-beta1 Positive_regulation (stimulated) of Gene_expression (production) of fibronectin in fibroblasts
4) Confidence 0.09 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20671605 Disease Relevance 0.08 Pain Relevance 0

General Comments

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