INT14714

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 4.41
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NPY) extracellular space (NPY) extracellular region (NPY)
cell (NPY)
Anatomy Link Frequency
joint 2
neurons 1
nerve 1
lumen 1
sympathetic 1
NPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 10 100.00 Very High Very High Very High
Desipramine 1 99.98 Very High Very High Very High
Opioid 8 99.96 Very High Very High Very High
noradrenaline 17 99.40 Very High Very High Very High
Inflammation 9 98.80 Very High Very High Very High
antagonist 26 98.56 Very High Very High Very High
withdrawal 102 98.36 Very High Very High Very High
Calcitonin gene-related peptide 9 98.12 Very High Very High Very High
Intracerebroventricular 2 97.94 Very High Very High Very High
Cholecystokinin 10 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 10 100.00 Very High Very High Very High
Helminth Infection 116 99.84 Very High Very High Very High
INFLAMMATION 9 98.80 Very High Very High Very High
Arthropathy 6 98.74 Very High Very High Very High
Weight Gain 10 92.40 High High
Hyperglycemia 2 91.36 High High
Increased Venous Pressure Under Development 7 90.28 High High
Insulin Resistance 10 89.84 High High
Obesity 218 86.60 High High
Diabetes Mellitus 34 83.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reserpine-induced depletion of NPY-LI, but not of NA, was highly dependent on intact nerve activity, since it was prevented by decentralization. 3.
Negative_regulation (depletion) of NPY in nerve
1) Confidence 0.58 Published 1988 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 3232527 Disease Relevance 0.09 Pain Relevance 0.16
Opioids, NPY and GHRH, which increase food intake, decrease sympathetic activity.
Negative_regulation (decrease) of NPY in sympathetic associated with opioid
2) Confidence 0.57 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8489134 Disease Relevance 0 Pain Relevance 0.41
After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity.
Negative_regulation (decrease) of NPY associated with calcitonin gene-related peptide
3) Confidence 0.51 Published 1990 Journal Hum. Reprod. Section Abstract Doc Link 1702449 Disease Relevance 0.09 Pain Relevance 0.56
The NA uptake inhibitor desipramine reduces NPY release.
Negative_regulation (reduces) of NPY associated with desipramine and noradrenaline
4) Confidence 0.43 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455193 Disease Relevance 0.22 Pain Relevance 0.64
In the patients with unspecific inflammatory joint disease there was also an improvement in the clinical variables and a reduction in the NPY-LI level after 2-3 weeks, but not on a statistically significant level.
Negative_regulation (reduction) of NPY in joint associated with inflammation and arthropathy
5) Confidence 0.42 Published 1996 Journal Acta Odontol. Scand. Section Abstract Doc Link 8669234 Disease Relevance 0.84 Pain Relevance 0.69
The results of this study show that intra-articular GC treatment causes a short-term decrease of the TMJ fluid level of NPY-LI in patients with specific inflammatory joint disease, while symptoms and signs improve.
Negative_regulation (decrease) of NPY in joint associated with snapping jaw, inflammation and arthropathy
6) Confidence 0.42 Published 1996 Journal Acta Odontol. Scand. Section Abstract Doc Link 8669234 Disease Relevance 1.08 Pain Relevance 0.67
Acute intracerebroventricular (icv) administration of a CaMKK2 null mice resulted in decreased food intake that was correlated with decreased hypothalamic NPY and AgRP mRNAs.
Negative_regulation (decreased) of NPY associated with intracerebroventricular
7) Confidence 0.25 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.63 Pain Relevance 0.24
Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.
Negative_regulation (loss) of NPY associated with qutenza and calcitonin gene-related peptide
8) Confidence 0.14 Published 1991 Journal Am. J. Anat. Section Abstract Doc Link 1719791 Disease Relevance 0 Pain Relevance 0.57
The resistance of CaMKK2 null mice to suppression of food intake by STO-609 infusion provides compelling evidence that CaMKK2 is the direct target of the drug and that the specific inhibition of CaMKK2 in NPY neurons is likely responsible for the reduced level of NPY and AgRP mRNAs and feeding behavior [100].
Negative_regulation (reduced) of NPY in neurons
9) Confidence 0.11 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC3010692 Disease Relevance 0.93 Pain Relevance 0.13
In C. elegans it has been reported that worms with a reduction of function of an NPY-like receptor, NPR-1, phenocopy ethanol withdrawal [17].
Negative_regulation (reduction) of NPY associated with helminth infection and withdrawal
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862703 Disease Relevance 0.36 Pain Relevance 0.24
It is released in the response to nutrients from the antrum, particularly lipids and proteins.42 It has been shown to be increased in older people and correlated with high levels of satiety and low hunger.43 Pancreatic polypeptide (PPY) is released by the distal intestine in the presence of nutrients in the lumen.44 PPY inhibits NPY and causes satiety.
Negative_regulation (inhibits) of NPY in lumen
11) Confidence 0.03 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920201 Disease Relevance 0.13 Pain Relevance 0.21

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