INT147149

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.85
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
plasma 2
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 31 98.88 Very High Very High Very High
antagonist 37 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
gABA 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 194 100.00 Very High Very High Very High
Acute Renal Failure 167 100.00 Very High Very High Very High
Burns 148 99.84 Very High Very High Very High
Injury 33 99.16 Very High Very High Very High
INFLAMMATION 43 98.88 Very High Very High Very High
Apoptosis 124 94.44 High High
Congenital Anomalies 5 92.40 High High
Hyperplasia 10 90.56 High High
Melanoma 24 87.84 High High
Skin Cancer 5 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cell content of E2F1 and Cyclin A, two proteins that promote cell cycle progression, were suppressed in both U251-MG and U87-MG human glioblastoma cell lines, whereas the level of p16(INK4A), a cell cycle inhibitor was upregulated.
Transcription (level) of INK4A
1) Confidence 0.67 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0
transcript of CDKN2A, aka ARF) [18].
Transcription (transcript) of ARF
2) Confidence 0.61 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.77 Pain Relevance 0
transcript of CDKN2A, aka ARF) [18].
Transcription (transcript) of CDKN2A
3) Confidence 0.61 Published 2008 Journal BMC Res Notes Section Body Doc Link PMC2564952 Disease Relevance 0.77 Pain Relevance 0
DNA hypermethylation can inhibit transcription of tumor suppressor genes and mismatch repair genes (p16, hMLH1 and VHL), providing an epigenetic mechanism of selection during tumorigenesis [11,12].
Transcription (transcription) of p16 associated with cancer
4) Confidence 0.53 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.12 Pain Relevance 0
The cell content of E2F1 and Cyclin A, two proteins that promote cell cycle progression, were suppressed in both U251-MG and U87-MG human glioblastoma cell lines, whereas the level of p16(INK4A), a cell cycle inhibitor was upregulated.
Transcription (level) of p16
5) Confidence 0.31 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0
Burns septic ARF group plasma altered tubular cell polarity
Transcription (polarity) of ARF in plasma associated with acute renal failure and burns
6) Confidence 0.24 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.91 Pain Relevance 0.06
Burns septic ARF group plasma altered cytoskeleton distribution and megalin expression in tubular cells
Transcription (distribution) of ARF in plasma associated with acute renal failure and burns
7) Confidence 0.24 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.85 Pain Relevance 0.09
In addition, statins affect G1/S transition control by over-expression at either the mRNA or protein level of Cdk inhibitors such as p16, -21, and -27 [335-337].
Transcription (mRNA) of p16
8) Confidence 0.07 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.42 Pain Relevance 0

General Comments

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