INT14715

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 2.22
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
plasma 2
SK-N-MC 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 55 100.00 Very High Very High Very High
headache 8 100.00 Very High Very High Very High
Catecholamine 7 99.88 Very High Very High Very High
Triptan 4 99.16 Very High Very High Very High
Clonidine 1 98.56 Very High Very High Very High
antagonist 7 98.36 Very High Very High Very High
Migraine 7 96.20 Very High Very High Very High
Sumatriptan 12 96.08 Very High Very High Very High
Somatostatin 3 88.72 High High
substance P 3 88.52 High High
Disease Link Frequency Relevance Heat
Headache 11 100.00 Very High Very High Very High
Cluster Headache 2 99.78 Very High Very High Very High
Heat Stress Disorders 11 99.70 Very High Very High Very High
Neuroblastoma 1 95.04 Very High Very High Very High
Increased Venous Pressure Under Development 2 90.28 High High
Neurogenic Inflammation 1 78.72 Quite High
Diabetes Mellitus 1 77.16 Quite High
Heart Rate Under Development 1 76.76 Quite High
Pressure Volume 2 Under Development 1 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP).
Negative_regulation (reducing) of Positive_regulation (circulating) of calcitonin gene-related peptide associated with cluster headache, triptan and calcitonin gene-related peptide
1) Confidence 0.43 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19266171 Disease Relevance 0.20 Pain Relevance 0.80
Triptans might exert their antimigraine effect by reducing the levels of circulating calcitonin gene-related peptide (CGRP).
Negative_regulation (reducing) of Positive_regulation (circulating) of CGRP associated with cluster headache, triptan and calcitonin gene-related peptide
2) Confidence 0.43 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19266171 Disease Relevance 0.20 Pain Relevance 0.80
Our results indicated that heat stress significantly increased the plasma concentration of CGRP, which was abolished by pretreatment with capsazepine, a VR1 antagonist.
Negative_regulation (abolished) of Positive_regulation (increased) of CGRP in plasma associated with antagonist, heat stress disorders and calcitonin gene-related peptide
3) Confidence 0.42 Published 2007 Journal Vascul. Pharmacol. Section Abstract Doc Link 17140857 Disease Relevance 0.56 Pain Relevance 0.67
After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity.
Negative_regulation (decrease) of Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide
4) Confidence 0.41 Published 1990 Journal Hum. Reprod. Section Abstract Doc Link 1702449 Disease Relevance 0.09 Pain Relevance 0.56
SB-(+)-273779 also inhibited CGRP (3 nM)-activated adenylyl cyclase in these systems with IC(50) values of 390 +/-10 nM (in SK-N-MC) and 210 +/-16 nM (recombinant human CGRP receptors).
Negative_regulation (inhibited) of Positive_regulation (-activated) of CGRP in SK-N-MC associated with calcitonin gene-related peptide
5) Confidence 0.40 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181905 Disease Relevance 0.46 Pain Relevance 0.81
We investigated the ability of BIBN4096BS to inhibit human alphaCGRP (h-alphaCGRP)-induced headache and cerebral hemodynamic changes in healthy volunteers.
Spec (investigated) Negative_regulation (inhibit) of Positive_regulation (-induced) of alphaCGRP associated with headache
6) Confidence 0.36 Published 2005 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 15735614 Disease Relevance 0.36 Pain Relevance 0.58
We investigated the ability of BIBN4096BS to inhibit human alphaCGRP (h-alphaCGRP)-induced headache and cerebral hemodynamic changes in healthy volunteers.
Spec (investigated) Negative_regulation (inhibit) of Positive_regulation (-induced) of h-alphaCGRP associated with headache
7) Confidence 0.36 Published 2005 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 15735614 Disease Relevance 0.36 Pain Relevance 0.58
Catecholamines also reduced cell proliferation, increased tartrate-resistant acid phosphatase (TRAcP) activity, interleukin 6 (IL-6) production, multi-nuclearity and response to salmon calcitonin (sCT) in undifferentiated FLG 29.1 cells.
Negative_regulation (reduced) of Positive_regulation (response) of salmon calcitonin associated with catecholamine
8) Confidence 0.05 Published 1996 Journal Osteoporos Int Section Abstract Doc Link 8845594 Disease Relevance 0 Pain Relevance 0.40

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