INT147151

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Cannabinoid 2 5.00 Very Low Very Low Very Low
cannabis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Delta-9-tetrahydrocannabinol 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 99.74 Very High Very High Very High
Pancreatic Cancer 30 95.52 Very High Very High Very High
Congenital Anomalies 4 90.72 High High
Retinoblastoma 2 85.52 High High
Glioma 2 82.08 Quite High
Skin Cancer 2 79.36 Quite High
Adenocarcinoma 16 62.52 Quite High
Malignant Neoplastic Disease 4 55.24 Quite High
Aggression 2 52.52 Quite High
Glioblastoma 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of p16 gene occurs through intragenic mutation, homozygous deletion and methylation associated transcriptional silencing.
Positive_regulation (occurs) of Negative_regulation (Inactivation) of p16
1) Confidence 0.47 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.68 Pain Relevance 0
In cancers, functional loss of p16INK4a occurs as a consequence of somatic mutations, homozygous and heterozygous deletions [6,7].
Positive_regulation (occurs) of Negative_regulation (loss) of p16INK4a associated with cancer
2) Confidence 0.47 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 1.05 Pain Relevance 0
The cell content of E2F1 and Cyclin A, two proteins that promote cell cycle progression, were suppressed in both U251-MG and U87-MG human glioblastoma cell lines, whereas the level of p16(INK4A), a cell cycle inhibitor was upregulated.
Positive_regulation (upregulated) of Negative_regulation (level) of INK4A
3) Confidence 0.45 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0

General Comments

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