INT147152

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.89
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (E2F1) nucleoplasm (E2F1) mitochondrion (E2F1)
nucleus (E2F1) DNA binding (E2F1) transcription factor binding (E2F1)
Anatomy Link Frequency
GBM 1
E2F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 4 97.36 Very High Very High Very High
Cannabinoid 8 96.56 Very High Very High Very High
Pain 4 93.56 High High
Inflammation 5 86.28 High High
Delta-9-tetrahydrocannabinol 4 81.48 Quite High
cINOD 1 66.64 Quite High
Central nervous system 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 4 99.60 Very High Very High Very High
Cancer 24 94.60 High High
Pain 4 93.56 High High
Vomiting 4 93.32 High High
INFLAMMATION 5 86.28 High High
Colon Cancer 4 75.00 Quite High
Metastasis 3 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decrease in E2F1 levels resulted from proteasome mediated degradation and was prevented by proteasome inhibitors.
Negative_regulation (decrease) of E2F1
1) Confidence 0.56 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Delta(9)-THC is shown to significantly affect viability of GBM cells via a mechanism that appears to elicit G(1) arrest due to downregulation of E2F1 and Cyclin A.
Negative_regulation (downregulation) of E2F1 in GBM
2) Confidence 0.56 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0
Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells.
Negative_regulation (downregulation) of E2F1 associated with glioblastoma
3) Confidence 0.56 Published 2008 Journal Acta Oncol Section Title Doc Link 17934890 Disease Relevance 0.55 Pain Relevance 0.31
The cell content of E2F1 and Cyclin A, two proteins that promote cell cycle progression, were suppressed in both U251-MG and U87-MG human glioblastoma cell lines, whereas the level of p16(INK4A), a cell cycle inhibitor was upregulated.
Negative_regulation (suppressed) of E2F1
4) Confidence 0.41 Published 2008 Journal Acta Oncol Section Body Doc Link 17934890 Disease Relevance 0 Pain Relevance 0
As expected, compared to the control (cells transfected with a siRNA vector specifically targeting GFP expression), E2F-1 knockdown could inhibit TSP-1 promoter (?
Negative_regulation (knockdown) of E2F-1
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.
Negative_regulation (decreased) of E2F1
6) Confidence 0.35 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19787257 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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