INT147159

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.96
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc3) ATPase activity (Abcc3) transmembrane transport (Abcc3)
Abcc3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 44 99.84 Very High Very High Very High
Bile 4 86.60 High High
ischemia 9 66.80 Quite High
Angina 2 18.16 Low Low
fibrosis 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 4 100.00 Very High Very High Very High
Hepatotoxicity 16 99.68 Very High Very High Very High
Breast Cancer 4 98.12 Very High Very High Very High
Diabetic Cardiomyopathies 14 91.00 High High
Diabetes Mellitus 135 87.76 High High
Insulin Resistance 4 85.40 High High
Myocardial Infarction 44 75.28 Quite High
Cardiovascular Disease 18 71.36 Quite High
Chronic Renal Failure 1 69.28 Quite High
Reperfusion Injury 2 67.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exceptions of Oatp1a1, Ntcp, and Mrp1, these data mirror previous results suggesting that the solution used to dissolve APAP may alter the susceptibility of mice to hepatotoxicity, but only minimally change the regulation of transporter gene expression.
Regulation (regulation) of Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity
1) Confidence 0.55 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.31 Pain Relevance 0.54
The purpose of this study was to determine whether using saline as a diluent for APAP alters regulation of transporter gene expression during hepatotoxicity.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity
2) Confidence 0.21 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.26 Pain Relevance 0.79
Alterations in transporter gene expression in this study were similar to those reported previously using propylene glycol as diluent.
Regulation (Alterations) of Gene_expression (expression) of transporter gene
3) Confidence 0.21 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.29 Pain Relevance 0.72
Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity.
Regulation (regulation) of Gene_expression (expression) of transporter gene associated with paracetamol and hepatotoxicity
4) Confidence 0.21 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Title Doc Link 17934960 Disease Relevance 0.28 Pain Relevance 0.84
In vivo administration of the antioxidant tempol (1 mmol/l in drinking water) for a period of 4-weeks to mice rendered insulin-resistant by deficiency of the insulin-sensitive GLUT4 transporter significantly and potently attenuated cardiac hypertrophy in concert with tempol up-regulated ventricular expression of thioredoxin-2 (confirming an antioxidant action) [101].
Regulation (regulated) of Gene_expression (expression) of transporter associated with coronary heart disease
5) Confidence 0.02 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2801857 Disease Relevance 1.83 Pain Relevance 0.09

General Comments

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