INT147162

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 21
Disease Relevance 7.29
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
CSCs 3
MCF-7 1
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.56 Very High Very High Very High
Potency 15 94.44 High High
Bile 40 92.04 High High
tolerance 9 77.76 Quite High
anesthesia 11 71.04 Quite High
dexamethasone 2 70.24 Quite High
Taxol 6 65.84 Quite High
Analgesic 1 48.20 Quite Low
palliative 1 46.36 Quite Low
rheumatoid arthritis 1 30.80 Quite Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 7 99.76 Very High Very High Very High
Cancer 602 98.36 Very High Very High Very High
Breast Cancer 379 96.08 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 100 95.12 Very High Very High Very High
Recurrence 33 93.52 High High
Endometriosis (extended) 5 89.20 High High
Disease 84 88.48 High High
Non-small-cell Lung Cancer 8 84.64 Quite High
Fever 7 83.64 Quite High
Colitis 2 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a considerable increase in the amount of MDR1 in both the MF-resistant parasites, AS-15MF and in AS-ATNMF1 in relation to the mdr1 single copy parasites AS-3CQ and AS-ATN (see Figure 5).
Positive_regulation (increase) of MDR1
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
In this context, we investigated by real time PCR whether the evolution of ATN + MF-resistance had selected parasites with increased mdr1 copy number or mRNA expression.
Positive_regulation (increased) of mdr1
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0.04
In line with an increase in mdr1 copy number, mRNA levels were also found to be increased in AS-ATNMF1, showing that the genomic amplification is accompanied by increased transcription (Figure 4).
Positive_regulation (increase) of mdr1
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
In contrast, multidrug resistance-associated proteins Mrp1, Mrp2, Mrp3, and Mrp4, as well as multidrug resistance proteins Mdr1a and Mdr1b genes, were increased following APAP.
Positive_regulation (increased) of Mdr1b associated with paracetamol
4) Confidence 0.51 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.30 Pain Relevance 0.86
These include upregulation of the ABCB1 or ABCG2 drug efflux pumps,58,63,64 downregulation of human organic cation transporter 1 (hOCT1) drug influx transporters,65,66 overexpression of Lyn, a Src-family kinase,67 and other Bcr-Abl-independent mechanisms.
Positive_regulation (upregulation) of ABCB1
5) Confidence 0.51 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.61 Pain Relevance 0.04
This enhanced cytotoxic effect has been attributed to epothilone being a poor substrate for p-glycoprotein drug resistance protein and having high affinity to the various ?
Positive_regulation (substrate) of p-glycoprotein
6) Confidence 0.49 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727900 Disease Relevance 0.36 Pain Relevance 0.05
Over-expression of survivin in MCF-7 cells due to transfection with survivin expression vectors results in decreasing sensitivity to cytotoxic drugs and activation of P-glycoprotein (MDR1), which exports drugs out of cells.
Positive_regulation (activation) of P-glycoprotein in MCF-7
7) Confidence 0.45 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.60 Pain Relevance 0
Downregulation of P-glycoprotein expression with the specific inhibitor verapamil markedly suppressed survivin mRNA expression, whereas no opposite effect of upregulated P-glycoprotein has been reported.
Positive_regulation (upregulated) of P-glycoprotein
8) Confidence 0.45 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.47 Pain Relevance 0
Epothilones are poor substrates for P-glycoprotein and are cytotoxic in cell lines that express high levels of P-glycoprotein (Lehne 2000).
Positive_regulation (levels) of P-glycoprotein
9) Confidence 0.45 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727900 Disease Relevance 0.22 Pain Relevance 0.03
Together, these findings suggest that quinacrine exposure altered the physical properties of PrPSc accumulating in MDR[0>] mice.


Positive_regulation (accumulating) of MDR
10) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.28 Pain Relevance 0.07
Interestingly, there was a small but significant increase of MDR1 protein in AS-ATN [1.4±0.0.17 (p?
Positive_regulation (increase) of MDR1
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
Investigation of candidate genes revealed an mdr1 duplication in the resistant parasites and increased levels of mdr1 transcripts and protein.
Positive_regulation (increased) of mdr1
12) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2904698 Disease Relevance 0.21 Pain Relevance 0
Thus, the fold-increase of AS-ATNMF1 mdr1 mRNA transcripts was 2.6±0.17 and 3.4±0.22, relative to its single copy number progenitor AS-ATN and to AS-3CQ, respectively.
Positive_regulation (increase) of mdr1
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
For AS-ATNMF1, the amount of MDR1 was augmented 5.6±0.44 fold when compared to AS-3CQ, and 4.5±0.80 fold in relation to AS-ATN (Figure 4).
Positive_regulation (augmented) of MDR1
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
MDR1 protein levels are increased in AS-ATNMF1
Positive_regulation (increased) of MDR1
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
Thus, AS-15MF displayed a 6.2±0.88 and 5.0±0.30 fold increase in MDR1 levels in comparison to AS-3CQ and AS-ATN, respectively (Figure 4).
Positive_regulation (increase) of MDR1
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0 Pain Relevance 0
In comparison to the non-treated cells, the number of cells expressing Sca-1 and MDR1 were enhanced by about 2-fold and 5-fold respectively after TGF?
Positive_regulation (enhanced) of MDR1
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.16 Pain Relevance 0
or doxorubicin increased the number of 4T1 cells expressing stem cell marker Sca-1 and the drug resistant transporter protein MDR1, and with the stem cell property of self-renewal as indicated by mammosphere formation.
Positive_regulation (increased) of MDR1 in stem cell
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.84 Pain Relevance 0
One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].
Positive_regulation (resistance) of P-glycoprotein in CSCs
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.30 Pain Relevance 0
One important feature of CSCs is their resistance to the cytotoxicity of varous chemotherapeutic agents because of their relatively high expression levels of multiple drug resistance transporters such as ABCB1 (MDR1/PGP, P-glycoprotein) and ABCG2 (MXR/BCRP) [38].
Positive_regulation (resistance) of MDR1 in CSCs
20) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 1.29 Pain Relevance 0

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