INT147163

Context Info Confidence 0.46 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.30 Pain Relevance 0.86

transport (Slco1b2) plasma membrane (Slco1b2) cytoplasm (Slco1b2)

Anatomy Link Frequency bile 1 Slco1b2 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 1 97.56 Paracetamol 11 97.28

Disease Link Frequency Relevance Heat Hepatotoxicity 4 84.72 Breast Cancer 1 72.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using the branched DNA signal amplification assay, reductions in organic anion-transporting polypeptides Oatp1a1, Oatp1b2, sodium/taurocholate-cotransporting polypeptide (Ntcp), and bile salt export pump (Bsep) mRNA were observed in APAP-treated mice.

Negative_regulation (reductions) of Oatp1b2 in bile associated with paracetamol and bile

1) Confidence 0.46 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.30 Pain Relevance 0.86

General Comments

This test has worked.