INT14717

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 10.67
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
plasma 5
neuronal 1
monocyte 1
liver 1
platelet 1
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 31 98.96 Very High Very High Very High
Angina 31 98.92 Very High Very High Very High
cva 14 98.84 Very High Very High Very High
transdermal 3 98.08 Very High Very High Very High
anesthesia 8 92.04 High High
Pain 2 87.88 High High
Inflammation 3 64.04 Quite High
abdominal pain 3 54.32 Quite High
metalloproteinase 2 33.00 Quite Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 104 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Cv General 3 Under Development 30 98.92 Very High Very High Very High
Thrombosis Related Under Development 10 98.84 Very High Very High Very High
Immunization 13 97.58 Very High Very High Very High
Disseminated Intravascular Coagulation 3 96.48 Very High Very High Very High
Cancer 82 95.56 Very High Very High Very High
Epstein-barr Virus 60 95.20 Very High Very High Very High
Diffuse Large B-cell Lymphoma 112 94.64 High High
Syndrome 14 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Median preoperative levels of thrombin-antithrombin complex (TAT), prothrombin fragment1+2 (F1+2), fibrin D-dimers and beta-thromboglobulin did not differ significantly in unstable and stable patients.
Gene_expression (levels) of TAT
1) Confidence 0.75 Published 2001 Journal Scand. Cardiovasc. J. Section Body Doc Link 11759123 Disease Relevance 0.08 Pain Relevance 0
METHODS: Including 21 patients, the following markers were measured preoperatively and on postoperative day 1, 2, 3, 7, 14, and 21: Activation products of coagulation: thrombin-antithrombin complex (TAT), thrombus precursor protein (TPP), and prothrombin-fragment F1+2 (F1+2), and markers of fibrinolysis: plasmin-alpha(2)-antiplasmin complexes (PAP), D-Dimer, tissue plasminogen activator (t-PA) antigen, and plasminogen activator inhibitor 1 (PAI-1) antigen.
Gene_expression (products) of TAT
2) Confidence 0.75 Published 2006 Journal Dermatol Surg Section Body Doc Link 16706757 Disease Relevance 0 Pain Relevance 0
The improvement in plasma TAT levels produced by administration of intravenous L-arginine or transdermal nitroglycerin suggests that intravascular coagulation is exacerbated by the decrease of NO production in patients with LPI.
Gene_expression (produced) of TAT in plasma associated with transdermal and disseminated intravascular coagulation
3) Confidence 0.75 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.30 Pain Relevance 0.19
Parents may therefore seek prenatal diagnosis, but this is not possible by biochemical assays as tyrosine does not accumulate in amniotic fluid and TAT is not expressed in chorionic villi or amniocytes.
Neg (not) Gene_expression (expressed) of TAT in amniotic fluid
4) Confidence 0.75 Published 2006 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 16917729 Disease Relevance 0.53 Pain Relevance 0.09
However, as TAT is expressed exclusively in liver, patient mRNA could not be obtained for splicing analysis.
Gene_expression (expressed) of TAT in liver
5) Confidence 0.75 Published 2006 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 16917729 Disease Relevance 0.43 Pain Relevance 0.06
Levels of plasma TAT and 11-dehydro-TXB2 were significantly higher (p < 0.05) in patients with prolonged rest angina than in those without the condition (n = 10).
Gene_expression (Levels) of TAT in plasma associated with angina
6) Confidence 0.75 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8480641 Disease Relevance 0.63 Pain Relevance 1.05
Although these conflicting results could be explained by differences in immunization regimen, viral stock, route of viral challenge and animal species, the result of two studies using similar viral vector expressing Tat, Env and Gag and giving opposite conclusion is puzzling [36,39].
Gene_expression (expressing) of Tat associated with immunization
7) Confidence 0.75 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.44 Pain Relevance 0
We generated human neuronal cell lines stably expressing several HIV-1 tat genes, and also tested human neuronal cells exposed to extracellular recombinant Tat protein.
Gene_expression (expressing) of tat in neuronal associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.75 Published 1994 Journal J. Gen. Virol. Section Abstract Doc Link 8046394 Disease Relevance 0.79 Pain Relevance 0.07
Both endogenously expressed Tat as well as exogenous recombinant Tat protein up-regulated HIV-1 long terminal region (LTR)-driven gene expression by several hundred-fold.
Gene_expression (expressed) of Tat associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.75 Published 1994 Journal J. Gen. Virol. Section Abstract Doc Link 8046394 Disease Relevance 0.77 Pain Relevance 0.06
VEGF promoter activity was downregulated in vitro in cells transfected with Tat.
Gene_expression (transfected) of Tat
10) Confidence 0.75 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.38 Pain Relevance 0
When compared to standard CPB, the Synergy showed lower levels of the monocyte-platelet adhesion index at T2 (0.023 +/- 0.005 vs 0.063 +/- 0.013, P = 0.0092) and T4 (0.031 +/- 0.003 vs 0.055 +/- 0.005, P = 0.0017), TAT complexes at T2 (27.175 +/- 5.967 vs 86.592 +/- 5.415, P = 0.0005) and T3 (26.977 +/- 2.468 vs 45.146 +/- 4.365, P = 0.0041), F1+2 fragments at T2 (2.222 +/- 0.226 vs 4.249 +/- 0.292, P = 0.0009), and sP-selectin at T3 (115.17 +/- 19.623 vs 169.554 +/- 19.709, P = 0.0703) and T4 (108.542 +/- 6.429 vs 140.799 +/- 14.771, P = 0.0833).
Gene_expression (levels) of TAT in monocyte associated with adhesions
11) Confidence 0.65 Published 2008 Journal Perfusion Section Abstract Doc Link 18788218 Disease Relevance 0.32 Pain Relevance 0.12
CONCLUSION: The TAT expectations of the ED physicians using the results of laboratory tests measuring myocardial injury exceed those of the laboratory personnel providing the results of those tests.
Gene_expression (expectations) of TAT
12) Confidence 0.65 Published 2004 Journal Arch. Pathol. Lab. Med. Section Body Doc Link 14736289 Disease Relevance 0 Pain Relevance 0
Studies of the relationship between coagulation (TAT-complexes) and fibrinolysis data revealed a significant positive correlation between plasma antigen concentrations of TAT-complexes and t-PA (P less than 0.02), and between TAT-complexes and PAI-I (P less than 0.002).
Gene_expression (concentrations) of TAT in plasma
13) Confidence 0.65 Published 1990 Journal J. Intern. Med. Section Abstract Doc Link 1702458 Disease Relevance 0.36 Pain Relevance 0.14
Thus, targeting Tat protein itself and stabilizing transient silencing of VEGF expression or use of monoclonal antibodies against their receptors in the AIDS-associated tumors will open a window for future explorable pathways in the management of angiogenic phenotypes in the AIDS-associated non-HodgkinÂ’s lymphomas (NHL) [8].
Gene_expression (targeting) of Tat associated with lymphatic system cancer, cancer and acquired immune deficiency syndrome or hiv infection
14) Confidence 0.65 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.59 Pain Relevance 0
To evaluate the effects of aspirin on thrombin generation in patients with unstable angina, plasma levels of thrombin-antithrombin III complex (TAT) as a new marker of thrombin generation and of 11-dehydro-thromboxane B2 (11-dehydro-TXB2) as an indicator of platelet activation were measured in 18 patients with unstable angina, including 8 patients with prolonged rest angina (> 15 minutes).
Gene_expression (generation) of TAT in platelet associated with aspirin and angina
15) Confidence 0.65 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8480641 Disease Relevance 0.44 Pain Relevance 0.71
Both endogenously expressed Tat as well as exogenous recombinant Tat protein up-regulated HIV-1 long terminal region (LTR)-driven gene expression by several hundred-fold.
Gene_expression (expression) of Tat associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.65 Published 1994 Journal J. Gen. Virol. Section Abstract Doc Link 8046394 Disease Relevance 0.77 Pain Relevance 0.06
Studies of the relationship between coagulation (TAT-complexes) and fibrinolysis data revealed a significant positive correlation between plasma antigen concentrations of TAT-complexes and t-PA (P less than 0.02), and between TAT-complexes and PAI-I (P less than 0.002).
Gene_expression (concentrations) of TAT in plasma
17) Confidence 0.65 Published 1990 Journal J. Intern. Med. Section Abstract Doc Link 1702458 Disease Relevance 0.36 Pain Relevance 0.14
At the cessation of antithrombin treatment, there was a clustering of cardiac events that tended to be related to a rise in the levels of TAT and the other markers.
Gene_expression (levels) of TAT
18) Confidence 0.58 Published 2001 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11397720 Disease Relevance 0.42 Pain Relevance 0.07
Mean levels of TAT and F1+2 were within the normal range preoperatively (TAT:2.6+1.0 microg/L, F1+2:0.8+0.2 nmol/L).
Gene_expression (levels) of TAT
19) Confidence 0.58 Published 1998 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 9804203 Disease Relevance 0.34 Pain Relevance 0.27
The pre- and postoperative levels of thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2) were studied in ten patients undergoing orthognathic surgery.
Gene_expression (levels) of TAT
20) Confidence 0.58 Published 1998 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 9804203 Disease Relevance 0.37 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox