INT147183

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 2.43
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (RNGTT) nucleoplasm (RNGTT) nucleus (RNGTT)
nucleotidyltransferase activity (RNGTT)
Anatomy Link Frequency
T cells 11
liver 1
THP-1 1
RNGTT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 97.56 Very High Very High Very High
cytokine 191 97.04 Very High Very High Very High
alcohol 3 78.36 Quite High
agonist 39 77.00 Quite High
Analgesic 3 70.08 Quite High
Inflammatory mediators 13 36.80 Quite Low
antagonist 14 29.60 Quite Low
Inflammatory response 39 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 166 97.56 Very High Very High Very High
Infection 65 96.44 Very High Very High Very High
Apoptosis 128 91.48 High High
Death 25 86.40 High High
Burns 13 85.76 High High
Injury 39 85.44 High High
Malignant Neoplastic Disease 13 82.44 Quite High
Skin Cancer 13 79.96 Quite High
Reprotox - General 1 13 79.44 Quite High
Cancer 15 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that there is little variation in hCE1 protein expression in HLM samples from 11 individuals [a 1.3-fold difference between the highest and lowest individuals; coefficient of variation (CV), 9%]. hCE2 protein expression in individual HLMs is only slightly more variable than hCE1 (2.3-fold difference between the highest and lowest individuals; CV, 36%).
Gene_expression (expression) of hCE1
1) Confidence 0.37 Published 2007 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 17936933 Disease Relevance 0 Pain Relevance 0.04
However, hCE1 protein is found in 46-fold higher amounts in HLMs than hCE2 protein (64.4 +/- 16.5 microg hCE1/mg microsomal protein compared to 1.4 +/- 0.2 microg hCE2/mg microsomal protein).
Gene_expression (found) of hCE1
2) Confidence 0.32 Published 2007 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 17936933 Disease Relevance 0 Pain Relevance 0.10
We have begun studies to evaluate the CE phenotype of human liver samples, i.e. to determine both the levels of hCE1 and hCE2 protein and the hydrolytic activity of each.
Spec (determine) Gene_expression (levels) of hCE1 in liver
3) Confidence 0.29 Published 2007 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 17936933 Disease Relevance 0 Pain Relevance 0.04
Our assays did not detect Nalp4, Nalp6, or Nalp12 either in HCE-T or in primary corneal cells, although the corresponding assays were verified by using other cell types that expressed these genes (data not shown).
Neg (not) Gene_expression (detect) of HCE
4) Confidence 0.22 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
A significantly lower expression of the procaspase-1 enzyme was found in HCE-T cells as compared to that measured in the PRK samples (Figure 2B).
Gene_expression (found) of HCE in T cells
5) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
production by HCE-T cells, but we did observe enhanced IL-6 secretion after 24 h of exposure.
Gene_expression (production) of HCE in T cells
6) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.41 Pain Relevance 0.09
Nalp7 was only detectable at a very low level in HCE-T cells whereas the expression of Nalp10 was dramatically higher in HCE-T cells than in the PRK samples.
Gene_expression (detectable) of HCE in T cells
7) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
These results show that the cellular response detected by transcriptional changes of NLR expression in HCE-T cells is accompanied by the enhanced secretion of the pro-inflammatory cytokine, IL-6, but not that of the biologically active IL-1?
Gene_expression (expression) of HCE in T cells associated with inflammation and cytokine
8) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.15 Pain Relevance 0.26
However, procaspase-1 was clearly detectable at the protein level in HCE-T cells, while no sign of its activation was observed, as also seen in unstimulated THP-1 cells (Figure 2C).
Gene_expression (detectable) of HCE in T cells
9) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
In our studies, the effect of UV light on the expression of the monitored NLR molecules in the HCE-T cells was different at early (6 h) and late (24 h) time points, and it also resulted in different changes of Nalps and Nods expression.
Gene_expression (expression) of HCE in T cells
10) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.84 Pain Relevance 0
Expression of inflammasome adaptors and enzymes in HCE-T cells after UV-B radiation
Gene_expression (Expression) of HCE in T cells
11) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.06 Pain Relevance 0
On the other hand, we could not detect the Nalp3 protein in HCE-T cells with the antibody that detected Nalp3 in THP-1 cells (data not shown).
Neg (not) Gene_expression (detect) of HCE in THP-1
12) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
The expression level of ASC adaptor was more than two orders of magnitude lower in HCE-T cells as compared to that measured in the PRK samples whereas the expression of Cardinal, a specific adaptor of the Nalp3 inflammasome, was similar in the two cell types.
Gene_expression (expression) of HCE in T cells
13) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
However, as some of the inflammasome components have dramatically altered expression pattern in HCE-T cells compared to the primary corneal cells, studies on primary cells are necessary to define the role of inflammasomes in UV-B mediated corneal processes.
Gene_expression (expression) of HCE in T cells
14) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.44 Pain Relevance 0.04
The time-dependent appearance of pIkB after PGN-ECndss treatment implies the presence of functional Nod1 and/or Nod2 proteins in HCE-T cells that are able to recognize the peptidoglycan ligand and trigger the NF?
Gene_expression (presence) of HCE in T cells
15) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.04
Effect of UV-B irradiation on the expression of Nod subtypes in HCE-T cells
Gene_expression (expression) of HCE in T cells
16) Confidence 0.20 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
We suggest that CD44 could be a key to understanding how HMW-HA protects HCE cells from UVB radiations.



Gene_expression (protects) of HCE
17) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.52 Pain Relevance 0.22

General Comments

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