INT1472

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2011
Negated 18
Speculated 7
Reported most in Abstract
Documents 349
Total Number 357
Disease Relevance 146.20
Pain Relevance 86.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 66
blood 25
muscle 11
liver 6
fat 6
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 274 100.00 Very High Very High Very High
narcan 126 100.00 Very High Very High Very High
Dopamine 117 100.00 Very High Very High Very High
Spinal cord 68 100.00 Very High Very High Very High
Bioavailability 62 100.00 Very High Very High Very High
Catecholamine 61 100.00 Very High Very High Very High
Enkephalin 48 100.00 Very High Very High Very High
Cholecystokinin 10 100.00 Very High Very High Very High
Morphine 101 99.98 Very High Very High Very High
tramadol 48 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 1033 100.00 Very High Very High Very High
Obesity 823 100.00 Very High Very High Very High
Body Weight 757 100.00 Very High Very High Very High
Metabolic Syndrome 649 100.00 Very High Very High Very High
Hyperlipidemia 351 100.00 Very High Very High Very High
Hyperinsulinism 281 100.00 Very High Very High Very High
Renal Failure 32 100.00 Very High Very High Very High
Appetite Loss 338 99.98 Very High Very High Very High
Impaired Glucose Tolerance 411 99.96 Very High Very High Very High
Hypoglycemia 159 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The morphine induced increase in insulin in the fed rats was abolished by naloxone treatment.
Positive_regulation (increase) of insulin associated with narcan and morphine
1) Confidence 0.69 Published 1993 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 8140390 Disease Relevance 0.10 Pain Relevance 1.28
Morphine increased insulin levels significantly in fed and fasted rats (p < 0.001), p < 0.01).
Positive_regulation (increased) of insulin associated with hyperinsulinism and morphine
2) Confidence 0.69 Published 1993 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 8140390 Disease Relevance 0.10 Pain Relevance 1.27
Insulin concentration was not increased, even when hyperglycemia was established.
Neg (not) Positive_regulation (increased) of Insulin associated with hyperglycemia
3) Confidence 0.69 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1282385 Disease Relevance 0.38 Pain Relevance 0.13
Nosedrops containing both a small amount of alkylglycoside (0.03-0.50%) and insulin (2 U regular porcine) caused a rapid decrease in blood D-glucose levels and a concomitant increase in serum immunoreactive insulin levels.
Positive_regulation (increase) of insulin in blood
4) Confidence 0.69 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988421 Disease Relevance 0 Pain Relevance 0.13
Anesthesia increased the insulin output during an OGTT in both strains of rats while glucose was unchanged.
Positive_regulation (increased) of insulin associated with anesthesia and sprains and strains
5) Confidence 0.69 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.09 Pain Relevance 0.38
In summary, SH rats are more insulin resistant than Wistar rats, and anesthesia, which elevated basal glucose and insulin levels and increased the insulin output in response to a glucose challenge, may increase insulin resistance.
Spec (may) Positive_regulation (increase) of insulin associated with anesthesia, hypertension and insulin resistance
6) Confidence 0.69 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.03 Pain Relevance 0.34
Pentobarbital anesthesia caused an elevation in basal glucose and insulin levels in Wistar rats at 9 and 16 weeks of age and in SH rats at 9 weeks.
Positive_regulation (elevation) of insulin associated with anesthesia and hypertension
7) Confidence 0.69 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.04 Pain Relevance 0.37
All animals were normoglycemic (-Cr, 109 +/- 3 mg/dL; +Cr, 119 +/- 5), with fasting insulin levels elevated in the -Cr group (65 +/- 10 microU/mL) versus the +Cr group (31 +/- 4 microU/mL).
Positive_regulation (elevated) of insulin
8) Confidence 0.69 Published 1998 Journal Metab. Clin. Exp. Section Abstract Doc Link 9550535 Disease Relevance 0.57 Pain Relevance 0.14
The alpha 2-adrenoceptor antagonist deriglidole (3 mg/kg i.p.) administered 30 min before glucose load slightly reduced glucose levels and markedly increased insulin levels both in D and DC rats.
Positive_regulation (increased) of insulin associated with antagonist and hyperinsulinism
9) Confidence 0.69 Published 1996 Journal Life Sci. Section Abstract Doc Link 8809210 Disease Relevance 0.90 Pain Relevance 0.61
In addition, intravenous amino acids administration during anesthesia induces an increase in the plasma insulin level.
Positive_regulation (increase) of insulin in plasma associated with anesthesia
10) Confidence 0.69 Published 2010 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 20495293 Disease Relevance 0.63 Pain Relevance 0.48
The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose-fed rats.
Positive_regulation (increase) of insulin in plasma associated with hypertension and clonidine
11) Confidence 0.69 Published 1987 Journal Hypertension Section Abstract Doc Link 3311990 Disease Relevance 0.70 Pain Relevance 0.10
The present study demonstrated that EA improved hyperglycemia in the fasting stage with a marked increase in plasma insulin levels.
Positive_regulation (increase) of insulin in plasma associated with hyperglycemia and electroacupuncture
12) Confidence 0.69 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19501858 Disease Relevance 0.43 Pain Relevance 0.65
Barbiturate treatment alone led to large increases of corticosterone and smaller but significant increases of glucose, insulin, and glucagon.
Positive_regulation (increases) of insulin
13) Confidence 0.69 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039355 Disease Relevance 0.14 Pain Relevance 0.16
Dynamics of glucose-induced plasma insulin increase in the rat fetus at different stages of gestation.
Positive_regulation (increase) of insulin in plasma
14) Confidence 0.69 Published 1979 Journal Biol. Neonate Section Title Doc Link 383163 Disease Relevance 0.43 Pain Relevance 0.07
The infusion of glucose raised the fetal blood glucose concentration to that of the mother and induced a rapid increase of plasma insulin levels on day 19.5 of gestation.
Positive_regulation (increase) of insulin in plasma
15) Confidence 0.69 Published 1979 Journal Biol. Neonate Section Abstract Doc Link 383163 Disease Relevance 0.40 Pain Relevance 0.08
This hypoglycaemic effect was accompanied by an increase in plasma insulin concentration.
Positive_regulation (increase) of insulin in plasma
16) Confidence 0.69 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2569525 Disease Relevance 0.15 Pain Relevance 0
During an i.v. glucose challenge, both plasma insulin and islet blood flow were increased in the two groups, but these increases were significantly higher in HG than in C rats.
Positive_regulation (increased) of insulin in blood
17) Confidence 0.69 Published 1997 Journal Endocrinology Section Abstract Doc Link 9112376 Disease Relevance 0 Pain Relevance 0.08
Acute section of the hepatic vagus nerve between the liver and the main anterior vagal trunk caused an increase in both arterial and portal plasma insulin concentrations.
Positive_regulation (increase) of insulin in trunk associated with vagus nerve
18) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 3891316 Disease Relevance 0 Pain Relevance 0.34
Intraperitoneal glucose enhanced arterial insulin more in sham-vagotomized than in hepatic-vagotomized rats.
Positive_regulation (enhanced) of insulin
19) Confidence 0.69 Published 1985 Journal Endocrinology Section Abstract Doc Link 3891316 Disease Relevance 0 Pain Relevance 0.32
At 4-h postblockade a 125-250% increase in peripheral plasma insulin levels occurred due to a combination of enhanced pancreatic insulin secretion and depressed hepatic insulin extraction.
Positive_regulation (increase) of insulin in plasma
20) Confidence 0.69 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 6989267 Disease Relevance 0.17 Pain Relevance 0.13

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