INT14724

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 233
Total Number 235
Disease Relevance 96.56
Pain Relevance 18.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
oocytes 5
uterine 4
body 3
embryo 3
follicles 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 67 100.00 Very High Very High Very High
intrathecal 1 99.98 Very High Very High Very High
agonist 3585 99.96 Very High Very High Very High
endometriosis 904 99.80 Very High Very High Very High
antiepileptic Drug 24 99.80 Very High Very High Very High
palliative 32 99.72 Very High Very High Very High
Lamotrigine 10 99.72 Very High Very High Very High
Pain 154 99.68 Very High Very High Very High
Spinal cord 8 99.40 Very High Very High Very High
cINOD 67 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 1690 100.00 Very High Very High Very High
Reprotox - General 1 1555 100.00 Very High Very High Very High
Endometriosis 350 100.00 Very High Very High Very High
Arthralgia 284 100.00 Very High Very High Very High
Dysmenorrhea 14 100.00 Very High Very High Very High
Reprotox - General 3 4087 99.84 Very High Very High Very High
Growth Problems 200 99.80 Very High Very High Very High
Pain 122 99.68 Very High Very High Very High
Cancer 1895 99.60 Very High Very High Very High
Targeted Disruption 42 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drugs inhibiting CYP19 were: lamotrigine, oxcarbazepine, tiagabine, phenobarbital, phenytoin, ethosuximide, and valproate.
Negative_regulation (inhibiting) of CYP19 associated with lamotrigine
1) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Abstract Doc Link 17959350 Disease Relevance 0.47 Pain Relevance 0.32
Inhibition of human aromatase complex (CYP19) by antiepileptic drugs.
Negative_regulation (Inhibition) of CYP19 associated with antiepileptic drug
2) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Title Doc Link 17959350 Disease Relevance 0.56 Pain Relevance 0.27
Twelve antiepileptic drugs, used in mono or polytherapy for the treatment of children, were tested for their ability to inhibit aromatase (CYP19) with commercially available microsomes from transfected insect cells using dibenzylfluorescein as substrate.
Negative_regulation (inhibit) of aromatase associated with antiepileptic drug
3) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Abstract Doc Link 17959350 Disease Relevance 0.51 Pain Relevance 0.27
The data for some of the AEDs show that side effects on steroid synthesis in humans due to inhibition of aromatase should be considered.
Negative_regulation (inhibition) of aromatase
4) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Abstract Doc Link 17959350 Disease Relevance 0.11 Pain Relevance 0.27
Twelve antiepileptic drugs, used in mono or polytherapy for the treatment of children, were tested for their ability to inhibit aromatase (CYP19) with commercially available microsomes from transfected insect cells using dibenzylfluorescein as substrate.
Negative_regulation (inhibit) of CYP19 associated with antiepileptic drug
5) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Abstract Doc Link 17959350 Disease Relevance 0.51 Pain Relevance 0.27
Inhibition of human aromatase complex (CYP19) by antiepileptic drugs.
Negative_regulation (Inhibition) of aromatase associated with antiepileptic drug
6) Confidence 0.59 Published 2008 Journal Toxicol In Vitro Section Title Doc Link 17959350 Disease Relevance 0.55 Pain Relevance 0.27
Aromatase deficiency is rare in humans.
Negative_regulation (deficiency) of Aromatase
7) Confidence 0.59 Published 2007 Journal Nature clinical practice. Endocrinology & metabolism Section Abstract Doc Link 17452968 Disease Relevance 0.22 Pain Relevance 0
This study examined whether or not 14 alpha-hydroxy-4-androstene-3,6,17-trione (14 alpha-OHAT), a new 4-androstene-3, 17-dione derivative synthesized microbiologically, inhibits estrogen biosynthetase (aromatase) activities of human uterine tumors (i.e. uterine endometrial cancer, uterine leiomyoma and uterine adenomyosis tissues). 14 alpha-OHAT inhibited aromatase activity in all uterine tumors, dose-dependently (0.1-10 microM).
Spec (whether) Negative_regulation (inhibits) of aromatase in uterine associated with uterine cancer, reprotox - general 3, endometriosis (extended) and dismenorea
8) Confidence 0.59 Published 1990 Journal J. Steroid Biochem. Section Abstract Doc Link 2214767 Disease Relevance 0.65 Pain Relevance 0.10
The compounds suppress aromatase enzyme activity in SK-BR-3 breast cancer cells in a dose and time-dependent manner, and structure activity analysis does not find a correlation between aromatase suppression and COX inhibition.
Negative_regulation (suppress) of aromatase enzyme in SK-BR-3 associated with breast cancer
9) Confidence 0.59 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.38 Pain Relevance 0.11
Treatment with COX-2 siRNAs decreased the expression of COX-2 mRNA; furthermore, the siCOX-2-mediated decrease also resulted in suppression of CYP19 mRNA.
Negative_regulation (suppression) of CYP19
10) Confidence 0.59 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.39 Pain Relevance 0.13
Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) and COX selective inhibitors can suppress CYP19 gene expression and decrease aromatase activity.
Negative_regulation (decrease) of aromatase associated with inflammation and cinod
11) Confidence 0.59 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.47 Pain Relevance 0.20
Moreover, the metabolites EDDP and norBUP were weaker inhibitors of aromatase than their parent compounds.
Negative_regulation (inhibitors) of aromatase
12) Confidence 0.59 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16455059 Disease Relevance 0 Pain Relevance 1.20
Dose-dependent decreases in aromatase activity were observed following treatment with an NSAID or COX inhibitor, with the most effective agents being COX selective inhibitors.
Negative_regulation (decreases) of aromatase associated with cinod
13) Confidence 0.58 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.52 Pain Relevance 0.36
Treatment of breast cancer cells with aromatase siRNAs suppressed CYP19 mRNA and aromatase enzyme activity.
Negative_regulation (suppressed) of CYP19 mRNA associated with breast cancer
14) Confidence 0.58 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.37 Pain Relevance 0.27
Finally, treatment with COX-2 siRNAs downregulated the expression of COX-2 mRNA; furthermore, the siCOX-2-mediated suppression of COX-2 also resulted in suppression of aromatase mRNA.
Negative_regulation (suppression) of aromatase mRNA
15) Confidence 0.58 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.34 Pain Relevance 0.23
Treatment of breast cancer cells with aromatase siRNAs suppressed CYP19 mRNA and aromatase enzyme activity.
Negative_regulation (suppressed) of aromatase enzyme associated with breast cancer
16) Confidence 0.58 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.37 Pain Relevance 0.27
They also block CYP19, a crucial enzyme involved in estrogen biosynthesis.
Negative_regulation (block) of CYP19
17) Confidence 0.58 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 11803026 Disease Relevance 0.31 Pain Relevance 0
Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: new questions--old answers?
Negative_regulation (inhibitors) of Aromatase associated with endometriosis
18) Confidence 0.58 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Title Doc Link 16157442 Disease Relevance 0.66 Pain Relevance 0.29
Aromatase activity in the microsomal fraction of adenomyotic tissues was inhibited by the addition of danazol, aromatase inhibitors, and anti-human placental P450arom monoclonal antibody (mAb3-2C2) in a manner similar to such inhibition in other human tissues.
Negative_regulation (inhibited) of Aromatase associated with dismenorea
19) Confidence 0.57 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9282984 Disease Relevance 0.97 Pain Relevance 0.52
Indeed, prostates of beagles shrunken after treatment with an aromatase inhibitor, further decreased in weight after additional treatment with cyproterone acetate, an antiandrogen.
Negative_regulation (inhibitor) of aromatase
20) Confidence 0.55 Published 1991 Journal Urology Section Abstract Doc Link 1702565 Disease Relevance 0.54 Pain Relevance 0.03

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