INT14726

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 8.23
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Mag)
Anatomy Link Frequency
neurons 2
liver 1
muscle 1
CSF 1
brain 1
Mag (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 3 100.00 Very High Very High Very High
intrathecal 704 99.98 Very High Very High Very High
headache 2 99.86 Very High Very High Very High
Multiple sclerosis 6 98.94 Very High Very High Very High
Lasting pain 80 98.90 Very High Very High Very High
Neuritis 8 94.64 High High
Spinal cord 330 93.56 High High
Eae 10 88.64 High High
Neuropathic pain 20 85.68 High High
Pain 54 83.92 Quite High
Disease Link Frequency Relevance Heat
Headache 2 99.86 Very High Very High Very High
Adhesions 17 99.60 Very High Very High Very High
Pancreatic Cancer 16 99.02 Very High Very High Very High
Demyelinating Disease 7 98.94 Very High Very High Very High
Pain 114 98.90 Very High Very High Very High
Neuropathy 8 98.64 Very High Very High Very High
Disease 38 98.18 Very High Very High Very High
Viral Meningitis 2 97.16 Very High Very High Very High
Coagulation Disorder 30 95.04 Very High Very High Very High
Experimental Autoimmune Neuritis 8 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myelin-associated glycoprotein (MAG), a membrane-bound protein expressed on oligodendrocytes and Schwann cells, binds myelin to neurons.
Gene_expression (expressed) of Myelin-associated glycoprotein in neurons
1) Confidence 0.42 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.84 Pain Relevance 0.08
Myelin-associated glycoprotein (MAG), a membrane-bound protein expressed on oligodendrocytes and Schwann cells, binds myelin to neurons.
Gene_expression (expressed) of MAG in neurons
2) Confidence 0.42 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.83 Pain Relevance 0.08
Immunohistochemical analysis of pancreatic perineural invasion showed the expression of both MUC1 and MAG.
Gene_expression (expression) of MAG
3) Confidence 0.42 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.74 Pain Relevance 0.05
Heterotypic adhesion assays between pancreatic cancer cells and Schwann cells revealed that increased expression of MUC1 or MAG enhanced adhesion.
Gene_expression (expression) of MAG in Schwann cells associated with pancreatic cancer and adhesions
4) Confidence 0.42 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.90 Pain Relevance 0.06
Our data suggest a pathogenic role of IgM antibodies against HNK adhesion carbohydrate epitope expressing PNS proteins P0, MAG and PMP-22.
Gene_expression (expressing) of MAG in PNS associated with peripheral nervous system and adhesions
5) Confidence 0.40 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982118 Disease Relevance 0.88 Pain Relevance 0.72
Among 165 patients with other neurologic diseases, including 60 with multiple sclerosis and 60 control subjects with tension headache, anti-MAG IgM antibodies were detected in the CSF from three patients (two with multiple sclerosis, one with aseptic meningitis), and in the serum sample of one patient with multiple sclerosis.
Gene_expression (detected) of MAG in CSF associated with multiple sclerosis, headache, viral meningitis and disease
6) Confidence 0.22 Published 1991 Journal Arch. Neurol. Section Abstract Doc Link 1702614 Disease Relevance 0.89 Pain Relevance 0.33
Intrathecal production of anti-MAG IgM antibodies is thus common in polyneuropathy associated with IgM monoclonal component.
Gene_expression (production) of MAG associated with neuropathy and intrathecal
7) Confidence 0.22 Published 1991 Journal Arch. Neurol. Section Abstract Doc Link 1702614 Disease Relevance 0.76 Pain Relevance 0.22
The overall goal of this study was to develop IT gene transfer yielding true long-term transgene expression defined as ?
Gene_expression (expression) of long-term associated with intrathecal
8) Confidence 0.01 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1373607 Disease Relevance 0.35 Pain Relevance 0.43
The present study addressed the question if rAAV vectors constitute a notable improvement upon other gene vectors currently used for IT rat studies on chronic pain, in particular, if rAAV vectors can mediate efficient long-term gene expression in this paradigm.
Gene_expression (expression) of long-term associated with lasting pain and intrathecal
9) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.10 Pain Relevance 0.22
rAAV2 is the best characterized type of rAAV vector and has been reported to mediate long-term gene expression in the brain, liver, muscle and other organs [20].
Gene_expression (expression) of long-term in muscle
10) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.09 Pain Relevance 0.30
Intrathecal long-term gene expression by self-complementary adeno-associated virus type 1 suitable for chronic pain studies in rats

Background

Gene_expression (expression) of long-term associated with lasting pain and intrathecal
11) Confidence 0.01 Published 2006 Journal Mol Pain Section Title Doc Link PMC1373607 Disease Relevance 0.35 Pain Relevance 0.47
The overall goal of the present study was to develop IT gene transfer yielding true long-term expression.
Gene_expression (expression) of long-term associated with intrathecal
12) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 1.04 Pain Relevance 0.40
Long-term gene expression
Gene_expression (expression) of Long-term
13) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0 Pain Relevance 0.24
In the present article, we show the result of our search for a better vector providing the first report of long-term gene expression after a single IT administration of any vector type.
Gene_expression (expression) of long-term associated with intrathecal
14) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.29 Pain Relevance 0.54
The major objective of this study was to identify a vector for IT gene transfer capable of long-term gene expression, i.e. beyond the two-week time point reported by all previous studies on IT gene transfer.
Gene_expression (expression) of long-term associated with intrathecal
15) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0 Pain Relevance 0.25
rAAV2 is the best characterized type of rAAV vector and has been reported to mediate long-term gene expression in the brain, liver, muscle and other organs [20].
Gene_expression (expression) of long-term in liver
16) Confidence 0.00 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.09 Pain Relevance 0.30
rAAV2 is the best characterized type of rAAV vector and has been reported to mediate long-term gene expression in the brain, liver, muscle and other organs [20].
Gene_expression (expression) of long-term in brain
17) Confidence 0.00 Published 2006 Journal Mol Pain Section Body Doc Link PMC1373607 Disease Relevance 0.09 Pain Relevance 0.30

General Comments

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