INT14727

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.95
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
plasma 1
hepatocytes 1
dermis 1
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 1 99.98 Very High Very High Very High
agonist 72 99.66 Very High Very High Very High
dexamethasone 8 99.56 Very High Very High Very High
rheumatoid arthritis 2 98.68 Very High Very High Very High
Nerve growth factor 6 97.72 Very High Very High Very High
spinal inflammation 1 88.76 High High
fibrosis 6 87.00 High High
Pain 10 83.68 Quite High
Kinase C 2 65.60 Quite High
cytokine 12 59.04 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 73 100.00 Very High Very High Very High
Fever 10 99.72 Very High Very High Very High
Uterine Fibroids 240 99.68 Very High Very High Very High
Rheumatoid Arthritis 50 98.68 Very High Very High Very High
Systemic Lupus Erythematosus 2 97.68 Very High Very High Very High
Death 18 94.56 High High
Keloid Scars 22 93.80 High High
Pressure And Volume Under Development 5 91.56 High High
Low Back Pain 1 88.76 High High
Syndrome 5 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of fibronectin on cryoprecipitate formation in rheumatoid arthritis and systemic lupus erythematosus.
Regulation (influence) of fibronectin associated with rheumatoid arthritis and systemic lupus erythematosus
1) Confidence 0.45 Published 1981 Journal Arthritis Rheum. Section Title Doc Link 7317115 Disease Relevance 0.55 Pain Relevance 0.18
The application of both TGF-beta1 and dexamethasone resulted in an additional effect on fibronectin; however, dexamethasone inhibited the TGF-beta1-induced NGF expression.
Regulation (effect) of fibronectin associated with nerve growth factor and dexamethasone
2) Confidence 0.18 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.15 Pain Relevance 0.71
Then we examined plasma type IV collagen 7S and fibronectin, because experimentally, corticosteroid regulates the extracellular matrix structure composed of type IV collagen, fibronectin and so on.
Regulation (regulates) of fibronectin in plasma associated with corticosteroid
3) Confidence 0.15 Published 1995 Journal Rinsho Shinkeigaku Section Abstract Doc Link 8521645 Disease Relevance 0.26 Pain Relevance 0.13
The immunohistochemical studies demonstrated increased deposition of TGF-beta, type VI collagen, and fibronectin epitopes in the extracellular matrix of the fascia in comparison to the adjacent dermis in the same specimens.
Regulation (epitopes) of fibronectin in dermis
4) Confidence 0.13 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.74 Pain Relevance 0.03
With ATRA treatment, leiomyoma cells demonstrated a down-regulation of fibronectin gene to levels comparable to myometrial expression patterns.
Regulation (regulation) of fibronectin gene associated with uterine fibroids
5) Confidence 0.13 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.76 Pain Relevance 0
In addition, the human genomic DNA amounts in the BAL pellets of FN samples were well within the tested limits of cross-reactivity with amplification by Aspergillus qPCR and hence inhibition due to human genomic DNA overload does not appear to be a factor affecting FN results.
Regulation (affecting) of FN
6) Confidence 0.08 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2440748 Disease Relevance 0.43 Pain Relevance 0
G-CSF prophylaxis is now recommended when the overall risk of febrile neutropenia (FN) due to regimen and individual patient factors is ?
Regulation (regimen) of FN associated with neutropenia and fever
7) Confidence 0.08 Published 2010 Journal Support Care Cancer Section Abstract Doc Link PMC2846279 Disease Relevance 0.58 Pain Relevance 0
regulation of ECM proteins such as collagens23 and fibronectin,26,27,29 and has also been demonstrated.
Regulation (regulation) of fibronectin
8) Confidence 0.08 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.53 Pain Relevance 0.10
2 by controlling the concentration of Fn in the solution.


Regulation (controlling) of Fn
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.38 Pain Relevance 0
Further, biochemical analyses supplement stereological data and demonstrate no changes in Fibronectin, Versican, GFAP, NG2, and PE-CAM1 protein expression at 2 weeks post-transplant.
Neg (no) Regulation (changes) of Fibronectin
10) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.15 Pain Relevance 0
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Neg (no) Regulation (changes) of Fibronectin
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
agonists, including TRO, CIG, ROSI, and PIO, in rat hepatocytes after a 6-hour treatment.
Regulation (after) of CIG in hepatocytes associated with agonist
12) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.49 Pain Relevance 0.05
Around 2-fold more genes were modulated in TRO- and CIG- than in ROSI- and PIO-treated cell samples.
Regulation (modulated) of CIG
13) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.50 Pain Relevance 0.05

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