INT1473

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Context Info
Confidence 0.80
First Reported 1977
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 95
Total Number 96
Disease Relevance 17.35
Pain Relevance 30.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gcg) extracellular region (Gcg) cytoplasm (Gcg)
Anatomy Link Frequency
pancreas 15
plasma 3
intestinal cells 1
muscle 1
tubules 1
Gcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 118 100.00 Very High Very High Very High
narcan 44 100.00 Very High Very High Very High
Enkephalin 30 100.00 Very High Very High Very High
anesthesia 27 100.00 Very High Very High Very High
Chronic pancreatitis 9 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
medulla 1 100.00 Very High Very High Very High
Catecholamine 14 99.98 Very High Very High Very High
Clonidine 69 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 15 100.00 Very High Very High Very High
Diabetes Mellitus 587 99.84 Very High Very High Very High
Hypoglycemia 23 99.82 Very High Very High Very High
Apoptosis 70 99.68 Very High Very High Very High
Aging 12 99.68 Very High Very High Very High
Hyperinsulinism 6 99.16 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 99.08 Very High Very High Very High
Impaired Glucose Tolerance 25 98.98 Very High Very High Very High
Nociception 3 98.64 Very High Very High Very High
Iron Overload 8 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infusion of clonidine (an alpha 2 agonist) caused significant increase of glucagon secretion even at a low dose of 0.5 nmol/kg/min, although infusion of neither an alpha 1 nor a beta 2 agonist caused it even at the high dose of 40.0 nmol/kg/min.
Localization (secretion) of glucagon associated with agonist and clonidine
1) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.29
It is concluded that the alpha 2 receptor mechanism plays the most important role in the adrenergic modulation of glucagon secretion in rats under physiological conditions.
Localization (secretion) of glucagon
2) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.25
Intravenous infusion of epinephrine alone (1 microgram/kg/min, equal to 0.7 nmol/kg/min) caused a significant increase in glucagon secretion.
Localization (secretion) of glucagon
3) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.24
Alpha 2-adrenergic modulation of pancreatic glucagon secretion in rats.
Localization (secretion) of glucagon
4) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Title Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.22
Phentolamine (an alpha blocker) or yohimbine (an alpha 2 blocker) administration completely inhibited the increase of glucagon secretion caused by epinephrine infusion, but neither the administration of bunazosin (an alpha 1 blocker) nor beta blockers inhibited it.
Localization (secretion) of glucagon associated with beta blocker
5) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.26
The present study was designed to clarify the mechanism of adrenergic modulation of pancreatic glucagon secretion in rats under physiological conditions by 1) epinephrine infusion alone or together with adrenergic blockers and 2) administration of adrenergic agonists.
Localization (secretion) of glucagon associated with agonist
6) Confidence 0.80 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1353630 Disease Relevance 0 Pain Relevance 0.16
Furthermore, comparisons of various kinds of indices among the different age groups, such as insulinogenic index, insulin/glucagon and so forth during oral glucose tolerance tests also indicate the significant alteration of glucagon secretion during aging process.
Localization (secretion) of glucagon associated with aging, tolerance and impaired glucose tolerance
7) Confidence 0.80 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477620 Disease Relevance 0.66 Pain Relevance 0.19
Oral glucose tolerance tests were performed under pentobarbital anesthesia in 43 male Wistar rats 2 to 18 months of age in order to determine if insulin and glucagon secretion are altered with aging.
Localization (secretion) of glucagon associated with anesthesia, aging, tolerance and impaired glucose tolerance
8) Confidence 0.80 Published 1979 Journal Endocrinol. Jpn. Section Abstract Doc Link 477620 Disease Relevance 0.36 Pain Relevance 0.15
The enhanced glucagon response to arginine and the nonsuppressibility of glucagon secretion by oral glucose found in these patients were similar to the results found in the same tests performed in our previous series of patients with "idiopathic" diabetes and at variance with those reported by others in patients with chronic pancreatitis.
Localization (secretion) of glucagon associated with diabetes mellitus and chronic pancreatitis
9) Confidence 0.79 Published 1977 Journal Diabetologia Section Abstract Doc Link 908475 Disease Relevance 0.79 Pain Relevance 0.09
Glucagon release induced by ventrolateral hypothalamic stimulation in the rat.
Localization (release) of Glucagon
10) Confidence 0.78 Published 1980 Journal Endocrinology Section Title Doc Link 6988208 Disease Relevance 0.20 Pain Relevance 0.13
These findings indicate that excitation of cutaneous nociceptive afferent information from the various spinal segments can regulate glucagon secretion from the pancreas as a reflex response, whose efferent limb is dually composed of both sympathetic and parasympathetic nerves.
Localization (secretion) of glucagon in spinal associated with nociception
11) Confidence 0.78 Published 1994 Journal Jpn. J. Physiol. Section Abstract Doc Link 7823413 Disease Relevance 0.10 Pain Relevance 0
The phospholipase A2 inhibitor mepacrine at 25 and 50 mumol/l significantly inhibited glucagon secretion induced by 0.1 mumol/l clonidine (P less than 0.01, respectively), whereas 5 mumol/l mepacrine did not affect clonidine-induced glucagon secretion.
Localization (secretion) of glucagon associated with clonidine
12) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.55
The phospholipase A2 inhibitor mepacrine at 25 and 50 mumol/l significantly inhibited glucagon secretion induced by 0.1 mumol/l clonidine (P less than 0.01, respectively), whereas 5 mumol/l mepacrine did not affect clonidine-induced glucagon secretion.
Localization (secretion) of glucagon associated with clonidine
13) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
Arachidonic acid metabolites and alpha 2-adrenoceptor-mediated glucagon secretion in rats.
Localization (secretion) of glucagon associated with aspirin
14) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Title Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.58
Effects of phospholipase A2 inhibitor, cyclooxygenase inhibitor and lipoxygenase inhibitor on glucagon secretion induced by the alpha 2-adrenergic agonist clonidine were studied in the isolated perfused rat pancreas.
Localization (secretion) of glucagon in pancreas associated with agonist and clonidine
15) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.42
Also, both 100 mumol/l acetylsalicylic acid (cyclooxygenase inhibitor) and 100 mumol/l caffeic acid (lipoxygenase inhibitor) significantly inhibited clonidine-induced glucagon secretion (P less than 0.01, respectively), whereas neither 10 mumol/l acetylsalicylic acid nor 10 mumol/l caffeic acid affected clonidine-induced glucagon secretion.
Localization (secretion) of glucagon associated with aspirin and clonidine
16) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.59
These results suggest that not only cyclooxygenase metabolites but also lipoxygenase metabolites are involved in the stimulation of glucagon secretion mediated through the alpha 2-adrenergic receptors in perfused rat pancreas.
Localization (secretion) of glucagon in pancreas
17) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.50
Also, both 100 mumol/l acetylsalicylic acid (cyclooxygenase inhibitor) and 100 mumol/l caffeic acid (lipoxygenase inhibitor) significantly inhibited clonidine-induced glucagon secretion (P less than 0.01, respectively), whereas neither 10 mumol/l acetylsalicylic acid nor 10 mumol/l caffeic acid affected clonidine-induced glucagon secretion.
Localization (secretion) of glucagon associated with aspirin and clonidine
18) Confidence 0.71 Published 1992 Journal Diabetes Res. Clin. Pract. Section Abstract Doc Link 1330464 Disease Relevance 0 Pain Relevance 0.57
These results suggest that the glucagon release which follows LHA electrical stimulation depends mainly on beta-adrenergic transmission by the splanchnic nerves.
Localization (release) of glucagon in nerves
19) Confidence 0.67 Published 1983 Journal Endocrinology Section Abstract Doc Link 6305629 Disease Relevance 0 Pain Relevance 0.40
Beta-receptor stimulation seems to contribute to the glucagon but not to the insulin release after morphine.
Localization (release) of glucagon associated with morphine
20) Confidence 0.65 Published 1993 Journal Life Sci. Section Abstract Doc Link 8102765 Disease Relevance 0 Pain Relevance 1.03

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