INT14731

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 78
Total Number 78
Disease Relevance 52.57
Pain Relevance 22.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
HGF 3
blood 2
ECM 2
keratinocyte 2
lungs 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 707 100.00 Very High Very High Very High
cytokine 419 100.00 Very High Very High Very High
antagonist 70 100.00 Very High Very High Very High
tail-flick 1 100.00 Very High Very High Very High
aspirin 402 99.98 Very High Very High Very High
Crohn's disease 68 99.82 Very High Very High Very High
fibrosis 218 99.72 Very High Very High Very High
chemokine 48 99.58 Very High Very High Very High
antidepressant 1 99.56 Very High Very High Very High
Peripheral nervous system 9 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 760 100.00 Very High Very High Very High
Fibrosis 253 100.00 Very High Very High Very High
Hypercalcemia 23 100.00 Very High Very High Very High
Osteoporosis 16 100.00 Very High Very High Very High
Camurati-engelmann Disease 14 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 326 99.96 Very High Very High Very High
Neurogenic Inflammation 3 99.90 Very High Very High Very High
Disease 610 99.82 Very High Very High Very High
Myasthenia Gravis 2 99.70 Very High Very High Very High
Emphysema 79 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In burn patients with HSc, serum IL-10 and transforming growth factor-beta (TGF-beta) levels were also significantly increased early after burn injury in patients who later developed HSc compared with normal volunteers and with a subset of burn patients who did not develop HSc, before returning to normal levels after 6 months.
Positive_regulation (increased) of TGF-beta associated with burns, injury and keloid scars
1) Confidence 0.67 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16542140 Disease Relevance 2.05 Pain Relevance 0.29
A number of growth factors play a specific role in regeneration and it has been proven that a previously described method of physically and chemically stimulating whole blood (to produce autologous conditioned serum) induces concentration increases in FGF-2, HGF, and TGF-beta1.
Positive_regulation (increases) of TGF-beta1 in HGF
2) Confidence 0.67 Published 2004 Journal Int J Sports Med Section Abstract Doc Link 15532001 Disease Relevance 1.26 Pain Relevance 0.08
AEA also showed a marked increase of interleukin Ibeta- converting enzyme (ICE)CED-3 family protease (caspase-3) activity.
Positive_regulation (increase) of CED associated with camurati-engelmann disease
3) Confidence 0.67 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12719786 Disease Relevance 0.85 Pain Relevance 0.21
However, the findings could also support a proatherogenic role of TGF-beta(1) resulting from the overexpression of LDL-binding proteoglycans.


Positive_regulation (role) of TGF-beta
4) Confidence 0.50 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.11 Pain Relevance 0
However, the findings could also support a proatherogenic role of TGF-beta(1) resulting from the overexpression of LDL-binding proteoglycans.


Positive_regulation (resulting) of TGF-beta
5) Confidence 0.50 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.10 Pain Relevance 0
1 resulted in a high level of TGF-?
Positive_regulation (level) of TGF
6) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.66 Pain Relevance 0.21
In contrast, there was a trend toward increased TGFbeta levels (increase by 42%; Figure 7B) which was nearly absent when cells had been pre-treated with a combination of AM251 and AM630 (increase by only 8%; Figure 7B).
Positive_regulation (increased) of TGFbeta
7) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.44 Pain Relevance 0.17
Increased TGF-beta(1) transcription and translation were associated with enhanced synthesis of extracellular matrix components including the collagen types I and III as shown by immunocytochemistry and enhanced incorporation of [3H]proline.
Positive_regulation (Increased) of TGF-beta in extracellular matrix
8) Confidence 0.47 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.17 Pain Relevance 0
Increased transforming growth factor beta in pure pancreatic juice in pancreatitis.
Positive_regulation (Increased) of transforming growth factor beta associated with pancreatitis
9) Confidence 0.46 Published 2001 Journal Pancreas Section Title Doc Link 11249075 Disease Relevance 1.00 Pain Relevance 0.48
However, joints with OA showed a more complex cytokine pattern, also involving IFN-gamma (P = 0.019), IL-ra (P = 0.047), and apparently but without reaching the chosen level of significance, IL-2, TNF-alpha and TGF-beta1,2,3.
Neg (without) Positive_regulation (reaching) of TGF-beta1 in joints associated with rheumatoid arthritis and cytokine
10) Confidence 0.45 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 14505622 Disease Relevance 0.51 Pain Relevance 0.67
Taken together, these results suggest that increasing the intra-articular levels of TGF-?
Positive_regulation (increasing) of TGF in articular
11) Confidence 0.45 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0 Pain Relevance 0
Control patients with myasthenia gravis had similarly elevated levels of IFN-gamma and TGF-beta and TGF-beta mRNA expressing blood MNC but lower numbers of IL-4-positive cells.
Positive_regulation (elevated) of TGF-beta mRNA in blood associated with myasthenia gravis
12) Confidence 0.44 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8080246 Disease Relevance 1.14 Pain Relevance 0.78
1 into the rabbit knee resulted in dose-dependent TGF-?
Positive_regulation (resulted) of TGF in knee
13) Confidence 0.42 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165041 Disease Relevance 0.45 Pain Relevance 0.07
Increasing doses of adenoviral vector expressing TGF-?
Positive_regulation (Increasing) of TGF
14) Confidence 0.42 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165041 Disease Relevance 0.26 Pain Relevance 0.05
Elevated TGF-?
Positive_regulation (Elevated) of TGF
15) Confidence 0.42 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.78 Pain Relevance 0.10
These experiments revealed significantly increased TGFbeta levels (by 130%, 185% and 204%, respectively) following coculture with donor, CP and sepsis PBMC (Figure 4A; p < 0.0001, p = 0.0002 and p = 0.0004, respectively).


Positive_regulation (increased) of TGFbeta associated with chronic pancreatitis and sepsis
16) Confidence 0.42 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.96 Pain Relevance 0.37
ASA (2 mM) was equally unable to increase TGF-?
Neg (unable) Positive_regulation (increase) of TGF associated with aspirin
17) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.32 Pain Relevance 0.47
Non-Smad pathways are emerging TGF-?
Positive_regulation (emerging) of TGF
18) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.37 Pain Relevance 0.35
In a previous study, however, we found that aspirin was unable to increase TGF-?
Neg (unable) Positive_regulation (increase) of TGF associated with aspirin
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.31 Pain Relevance 0.41
The authors of this study previously reported6,7 on what was thought to be the first' biochemical studies showing increased concentrations of transforming growth factor-beta 1 (TGF-?
Positive_regulation (increased) of transforming growth factor-beta 1
20) Confidence 0.40 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0.81 Pain Relevance 0.20

General Comments

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