INT14732

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 46
Total Number 49
Disease Relevance 31.17
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
plasma 3
cartilage 2
TMJ 2
extracellular matrix 2
placenta 2
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 171 100.00 Very High Very High Very High
Inflammation 163 100.00 Very High Very High Very High
alcohol 27 100.00 Very High Very High Very High
metalloproteinase 13 100.00 Very High Very High Very High
Snapping jaw 15 99.60 Very High Very High Very High
Osteoarthritis 59 99.00 Very High Very High Very High
Chronic pancreatitis 202 98.96 Very High Very High Very High
Brush evoked pain 4 98.44 Very High Very High Very High
rheumatoid arthritis 151 98.24 Very High Very High Very High
Sciatic nerve 10 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 491 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 462 100.00 Very High Very High Very High
Boutonneuse Fever 282 100.00 Very High Very High Very High
INFLAMMATION 177 100.00 Very High Very High Very High
Neutropenia 144 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Adhesions 241 99.60 Very High Very High Very High
Myocardial Infarction 96 99.60 Very High Very High Very High
Temporomandibular Joint Syndrome 15 99.60 Very High Very High Very High
Fever 81 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus alterations in the structure of cartilage fibronectin do not appear to correlate with the increased level of fibronectin protein associated with osteoarthritis.
Positive_regulation (increased) of fibronectin in cartilage associated with osteoarthritis
1) Confidence 0.69 Published 1995 Journal Osteoarthr. Cartil. Section Abstract Doc Link 8581748 Disease Relevance 0.75 Pain Relevance 0.14
Indeed, accumulation of extracellular matrix proteins, such as laminin and fibronectin, is a hallmark of the development of HF [38], and ITGB1 protects the heart from ventricular dysfunction and failure [39].
Positive_regulation (accumulation) of fibronectin in heart associated with cv unclassified under development and myocardial infarction
2) Confidence 0.64 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.05 Pain Relevance 0.04
Finally, dramatic increases in MSF cases during the 1970s may be related to the advent of new diagnostic methods, such as microimmunofluorescence and the increased interest in traveling to several countries such as France, Italy, and Spain.
Positive_regulation (increases) of MSF associated with boutonneuse fever
3) Confidence 0.57 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 0.91 Pain Relevance 0.06
This increase in MSF cases in the 1970s could also have been caused by a shift in effectiveness of prescribed antimicrobial drugs.
Positive_regulation (increase) of MSF associated with boutonneuse fever
4) Confidence 0.57 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 0.62 Pain Relevance 0
For example, the dramatic increase in MSF cases in Oran, Algeria, is mainly due to the renewed interest in the disease by 1 physician (2).
Positive_regulation (increase) of MSF associated with disease and boutonneuse fever
5) Confidence 0.57 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.33 Pain Relevance 0
We examined the splicing patterns of fibronectin mRNA from adult human articular cartilage of normal and osteoarthritic joints by RNase protection (exon IIIA and exon IIIB) and reversed transcription-polymerase chain reaction (exon V) assays to determine whether or not the increased fibronectin content in osteoarthritic cartilage is also associated with differences in the splicing patterns of these three alternatively spliced exons.
Spec (whether) Positive_regulation (increased) of fibronectin in cartilage associated with osteoarthritis
6) Confidence 0.50 Published 1995 Journal Osteoarthr. Cartil. Section Abstract Doc Link 8581748 Disease Relevance 0.76 Pain Relevance 0.15
We detect the induction of both fibronectin and PAI1 in NHEK cells at both 12 and 24 hrs, suggesting a role of EGR1 pathways in the NAC mediated mechanism at least in this cell type.
Positive_regulation (induction) of fibronectin
7) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.43 Pain Relevance 0
Fibronectin upregulation in human temporomandibular joint disks with internal derangement.
Positive_regulation (upregulation) of Fibronectin in temporomandibular joint associated with snapping jaw
8) Confidence 0.47 Published 2004 Journal J Craniofac Surg Section Title Doc Link 15213552 Disease Relevance 0.57 Pain Relevance 0.48
The hypothesis of this study is that TMJ discs and serum of patients with closed lock will contain an increased amount of fibronectin and decreased amount of collagen I.
Positive_regulation (increased) of fibronectin in TMJ associated with snapping jaw
9) Confidence 0.45 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.75 Pain Relevance 0.54
In animal models of eccentric exercise-induced injury, disruption of the cytoskeleton and the sarcolemma of muscle fibres occurs within the first hour after the exercise, since a rapid loss of staining of desmin, a cytoskeletal protein, and the presence of fibronectin, a plasma and extracellular protein, are observed within the muscle fibres.
Positive_regulation (presence) of fibronectin in muscle associated with injury
10) Confidence 0.40 Published 2002 Journal Histochem. Cell Biol. Section Abstract Doc Link 12122444 Disease Relevance 0.70 Pain Relevance 0
This gene list includes FN1, ITGB8, THBS2, HNT and CDH10.
Positive_regulation (includes) of FN1
11) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.11 Pain Relevance 0
For example, both methods falsely classified report 62 as “no personal history” (Q1), creating an FN for each.
Positive_regulation (creating) of FN
12) Confidence 0.29 Published 2010 Journal Journal of Pathology Informatics Section Body Doc Link PMC2956176 Disease Relevance 0 Pain Relevance 0
Stimulation of the femoral nerve (FN) elicited a short-latency monosynaptic Ia facilitation of the soleus H-reflex.
Positive_regulation (Stimulation) of FN in soleus
13) Confidence 0.22 Published 1995 Journal Exp Brain Res Section Abstract Doc Link 7621944 Disease Relevance 0 Pain Relevance 0.08
Our results eliminate a role for a number of potential opsonins, including complement, pentraxin-3, and fibronectin.
Positive_regulation (role) of fibronectin
14) Confidence 0.21 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597001 Disease Relevance 1.02 Pain Relevance 0.24
TNFalpha induced an increase in collagen1 (p = 0.069) and an increase in fibronectin levels (p = 0.007).


Positive_regulation (increase) of fibronectin
15) Confidence 0.20 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.71 Pain Relevance 0.09
Densitometry adjusted to control PSC supernatants revealed that LPS increased collagen secretion (Figure 3A, p < 0.001) and induced a trend towards increased fibronectin levels (Figure 3A).
Positive_regulation (increased) of fibronectin associated with primary sclerosing cholangitis
16) Confidence 0.20 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.65 Pain Relevance 0.03
Using CP PBMC, this effect was more pronounced, with a 126% increase in fibronectin, whereas in septic shock PBMC there was a 104% increase (Figure 4B).
Positive_regulation (increase) of fibronectin associated with chronic pancreatitis and sepsis
17) Confidence 0.20 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.85 Pain Relevance 0.26
Moreover, this site specific variance in ECM deposition can be due to the following reasons: 1) The packed immune clusters are actually forming in expanded perivascular spaces as hinted by the presence of central CD31 positive endothelial cells; 2) In vitro, the matrix degradation enzyme MMP-1 was increased together with an increase in ECM proteins collagen1 and fibronectin; 3) High amounts of TNFalpha exert cytotoxic effects on PSC [20] which is probably represented in vivo as a function of their density.
Positive_regulation (increase) of fibronectin in endothelial cells associated with primary sclerosing cholangitis
18) Confidence 0.18 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.60 Pain Relevance 0.03
To examine ECM effects on neural differentiation of hESC in vitro, the treated polystyrene 35 mm cell culture dishes (Corning, NY; ) were coated with the following substrates: Poly-D-Lysine (PDL), human placenta-derived fibronectin (FN), human placenta-derived laminin (LN), type I collagen and Matrigel.
Positive_regulation (derived) of fibronectin in placenta
19) Confidence 0.17 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.13 Pain Relevance 0
To examine ECM effects on neural differentiation of hESC in vitro, the treated polystyrene 35 mm cell culture dishes (Corning, NY; ) were coated with the following substrates: Poly-D-Lysine (PDL), human placenta-derived fibronectin (FN), human placenta-derived laminin (LN), type I collagen and Matrigel.
Positive_regulation (derived) of FN in placenta
20) Confidence 0.17 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.14 Pain Relevance 0

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