INT14733

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 71
Total Number 79
Disease Relevance 49.89
Pain Relevance 22.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
epithelial cells 10
articular 6
smooth muscle cells 4
PNS 4
extracellular matrix 4
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 850 100.00 Very High Very High Very High
cytokine 281 100.00 Very High Very High Very High
aspirin 204 100.00 Very High Very High Very High
Pain 112 100.00 Very High Very High Very High
Chronic pancreatitis 58 100.00 Very High Very High Very High
Peripheral nervous system 27 100.00 Very High Very High Very High
Nerve growth factor 12 100.00 Very High Very High Very High
tail-flick 1 100.00 Very High Very High Very High
Neuritis 32 99.98 Very High Very High Very High
Opioid 13 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 932 100.00 Very High Very High Very High
Pancreatitis 73 100.00 Very High Very High Very High
Stress 69 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 30 99.98 Very High Very High Very High
Adenocarcinoma 137 99.84 Very High Very High Very High
Cancer 474 99.72 Very High Very High Very High
Fibrosis 315 99.72 Very High Very High Very High
Apoptosis 152 99.72 Very High Very High Very High
Myasthenia Gravis 1 99.70 Very High Very High Very High
Hypertrophy 17 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous nitric oxide causes overexpression of TGF-beta1 and overproduction of extracellular matrix in human coronary smooth muscle cells.
Positive_regulation (causes) of Gene_expression (overexpression) of TGF-beta1 in smooth muscle cells
1) Confidence 0.69 Published 2003 Journal Cardiovasc. Res. Section Title Doc Link 12798441 Disease Relevance 0 Pain Relevance 0.09
Overexpressed TGF-beta(1) could stabilize the fibrous cap overlaying atherosclerotic plaques due to the accumulation of extracellular matrix components.
Positive_regulation (Overexpressed) of Gene_expression (Overexpressed) of TGF-beta in extracellular matrix
2) Confidence 0.69 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.12 Pain Relevance 0
RESULTS: Cells exposed to 100 microM DETA/NO for 48-72 h were channeled into a cell cycle-arrested hypertrophic growth status associated with overexpression of TGF-beta(1) on both the protein and mRNA levels.
Neg (NO) Positive_regulation (overexpression) of Gene_expression (overexpression) of TGF-beta
3) Confidence 0.69 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.17 Pain Relevance 0
CONCLUSIONS: Our results suggest a dual function of the overexpressed TGF-beta(1).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TGF-beta
4) Confidence 0.69 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.12 Pain Relevance 0
The aim of our study was to investigate the influence of peritoneal fluid (PF) from endometriosis patients on cultured neural cells that are the morphological basis of nociception, and to determine whether there was a relationship between the rAFS staging and an elevation of TGF-beta1 production by these cells.
Spec (whether) Positive_regulation (elevation) of Gene_expression (production) of TGF-beta1 in neural associated with nociception and endometriosis
5) Confidence 0.69 Published 2009 Journal Gynecol. Endocrinol. Section Abstract Doc Link 19908949 Disease Relevance 1.10 Pain Relevance 0.72
Osteocalcin synthesis and TGF-beta1 production were significantly stimulated on the samples exposed to 3 J/cm2.
Positive_regulation (stimulated) of Gene_expression (production) of TGF-beta1
6) Confidence 0.69 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.14 Pain Relevance 0
Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome.
Positive_regulation (Elevated) of Gene_expression (expression) of transforming growth factor-beta 1 associated with pain, syndrome, fasciitis, myalgia and eosinophilia
7) Confidence 0.67 Published 1991 Journal J. Invest. Dermatol. Section Title Doc Link 1702819 Disease Relevance 0.85 Pain Relevance 0.13
However, PG synthesis and endogenous TGF-beta1 production increased and demonstrated a synergistic effect between LIPUS and TGF-beta.
Positive_regulation (increased) of Gene_expression (production) of TGF-beta1
8) Confidence 0.61 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17593536 Disease Relevance 0 Pain Relevance 0.08
This hypothesis is supported by data in the literature showing enhanced TGFbeta expression in human chronic pancreatitis (2) and development of fibrosis and inflammation in pancreata of transgenic mice overexpressing TGFbeta1 (3).
Positive_regulation (enhanced) of Gene_expression (expression) of TGFbeta associated with targeted disruption, fibrosis, inflammation and chronic pancreatitis
9) Confidence 0.51 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.89 Pain Relevance 0.38
To verify the functional implication of TGFbeta overexpression in regulating extracellular matrix remodeling during regeneration from acute pancreatitis, rats were treated with 3 injections of neutralizing antibody against TGFbeta1 given 30 min before, and 24 hours and 48 hours after the start of infusion.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TGFbeta in extracellular matrix associated with pancreatitis
10) Confidence 0.51 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.33 Pain Relevance 0.03
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
11) Confidence 0.50 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
12) Confidence 0.50 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Positive_regulation (pancreatitis) of Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
13) Confidence 0.50 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
In chronic pancreatitis, TGF-beta 1 precursor was detected mainly in mononuclear cells located in the fibrotic areas and also in ducts damaged by fibrosis, more frequently in calcifying chronic pancreatitis.
Positive_regulation (pancreatitis) of Gene_expression (detected) of TGF-beta 1 precursor in ducts
14) Confidence 0.50 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.08 Pain Relevance 0
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Positive_regulation (pancreatitis) of Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
15) Confidence 0.50 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
To determine whether overexpression of TGF-?
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of TGF
16) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.30 Pain Relevance 0.11
In contrast to the adverse effects of intra-articular adenoviral gene transfer of TGF-?
Positive_regulation (transfer) of Gene_expression (transfer) of TGF in articular
17) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0 Pain Relevance 0
However, TGF-?
Positive_regulation (However) of Gene_expression (However) of TGF
18) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.67 Pain Relevance 0.21
1 virus into the rabbit knee resulted in dose-dependent elevated levels of expression of TGF-?
Positive_regulation (elevated) of Gene_expression (expression) of TGF in knee
19) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.83 Pain Relevance 0.29
1 on the regulation of cartilage synthesis and other articular pathologies, we used adenovirus-mediated intra-articular gene transfer of TGF-?
Positive_regulation (transfer) of Gene_expression (transfer) of TGF in articular
20) Confidence 0.49 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165041 Disease Relevance 0.24 Pain Relevance 0.04

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