INT147336

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 7.27
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-G)
Anatomy Link Frequency
leukocyte 2
endometrium 2
eye 1
retina 1
endothelial cells 1
HLA-G (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 98.48 Very High Very High Very High
Dismenorea 12 98.20 Very High Very High Very High
Inflammatory marker 2 98.02 Very High Very High Very High
cytokine 19 97.24 Very High Very High Very High
tolerance 3 87.00 High High
chemokine 19 83.76 Quite High
Inflammatory response 4 81.76 Quite High
abdominal pain 1 73.04 Quite High
potassium channel 1 57.92 Quite High
Multiple sclerosis 2 30.56 Quite Low
Disease Link Frequency Relevance Heat
Lung Cancer 272 99.62 Very High Very High Very High
INFLAMMATION 42 98.48 Very High Very High Very High
Aging 99 98.28 Very High Very High Very High
Dysmenorrhea 12 98.20 Very High Very High Very High
Cancer 153 96.24 Very High Very High Very High
Syndrome 5 95.34 Very High Very High Very High
Increased Venous Pressure Under Development 3 95.16 Very High Very High Very High
Herpes Simplex Virus 4 93.68 High High
Diabetic Retinopathy 2 91.88 High High
Age-related Macular Degeneration 28 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION(S): Patients with adenomyosis had HLA-G expression in eutopic and ectopic endometrial cells.
Gene_expression (expression) of HLA-G
1) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17953947 Disease Relevance 0.06 Pain Relevance 0
We found that MM cells only rarely express HLA-G, but that expression is significantly higher in effusions (Figure 1-I), suggesting that cells at this site may utilize this surface molecule to evade the immune response in effusions (Kleinberg, 2006).
Gene_expression (express) of HLA-G associated with lung cancer
2) Confidence 0.75 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.05 Pain Relevance 0.14
In the first study, we analyzed the expression of HLA-G, a non-classical major histocompatibility complex (MHC) class I that has been hypothesized to mediate cancer cell evasion of the host immune response (Algarra, 2004).
Spec (analyzed) Gene_expression (expression) of HLA-G associated with cancer
3) Confidence 0.75 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.18 Pain Relevance 0.10
Increased expression of H2-K1 and the human homolog, HLA-C, was also reported in previous studies of aging mouse and human retina and eye tissue [1], [26], [27].
Gene_expression (expression) of HLA-C in retina associated with aging
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 1.16 Pain Relevance 0.13
OBJECTIVE: To compare the expression of human leukocyte antigen-G (HLA-G) in endometrial samples from patients with and without adenomyosis.
Gene_expression (expression) of HLA-G in leukocyte associated with dismenorea
5) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17953947 Disease Relevance 0.17 Pain Relevance 0.17
RESULT(S): A statistically significant difference was noted in HLA-G expression between the glandular cells of eutopic and ectopic endometrium (Mann-Whitney test, 412).
Gene_expression (expression) of HLA-G in endometrium
6) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17953947 Disease Relevance 0.08 Pain Relevance 0
A statistically significant correlation was found between HLA-G expression in ectopic and eutopic endometrium in patients with adenomyosis, both in glands (r = 0.89) and in stroma (r = 0.78).
Gene_expression (expression) of HLA-G in glands
7) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17953947 Disease Relevance 0.06 Pain Relevance 0
In stromal cells, we observed a statistically significantly higher expression of HLA-G in eutopic endometrium than in ectopic endometrium (Mann-Whitney test, 169), whereas the H-score of the negative control was 0.05 +/- 0.02.
Gene_expression (expression) of HLA-G in endometrium
8) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17953947 Disease Relevance 0.07 Pain Relevance 0
MAIN OUTCOME MEASURE(S): Quantitative analysis of HLA-G protein expression, according to H-score.
Gene_expression (expression) of HLA-G
9) Confidence 0.75 Published 2008 Journal Fertil. Steril. Section Body Doc Link 17953947 Disease Relevance 0.09 Pain Relevance 0
They express high levels of inhibitory immunoglobulin like transcript (ILT) receptors, particularly ILT4, and its ligand, HLA-G.
Gene_expression (express) of HLA-G
10) Confidence 0.58 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.23 Pain Relevance 0.10
These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).
Gene_expression (molecules) of HLA-G in immune cells associated with cytokine
11) Confidence 0.29 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.31 Pain Relevance 0.12
Increased expression of H2-K1 and the human homolog, HLA-C, was also reported in previous studies of aging mouse and human retina and eye tissue [1], [26], [27].
Gene_expression (expression) of HLA-C in eye associated with aging
12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 1.16 Pain Relevance 0.13
The patient was referred to our hospital, and suspected to have vasculitis syndrome since the abnormal laboratory findings included persistently increased levels of FDP-E/fibrin monomer as well as inflammatory markers, and the extraordinary high excretion of beta 2-microglobulin, which indicated abrupt and massive expression of HLA class I molecule on endothelial cells due to interferon-gammanemia.
Gene_expression (expression) of HLA class I molecule in endothelial cells associated with syndrome, inflammatory marker and increased venous pressure under development
13) Confidence 0.24 Published 2008 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 18974626 Disease Relevance 1.47 Pain Relevance 0.15
Overall, 112 peptides (70%) had a binding affinity (KD) of 500 nM or less for the relevant HLA class I molecule (Supplementary Table S1).
Gene_expression (relevant) of class I molecule
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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