INT147338

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.80
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Synm) cytoskeleton (Synm) protein binding, bridging (Synm)
biological_process (Synm) cytoplasm (Synm)
Synm (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 24 98.14 Very High Very High Very High
Hippocampus 6 96.16 Very High Very High Very High
depression 9 83.20 Quite High
antidepressant 3 73.68 Quite High
Disease Link Frequency Relevance Heat
Recurrence 3 99.04 Very High Very High Very High
Depression 9 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas LH animals treated 21 days with saline (LH-S group) displayed diminished SYN and PSD-95 immunostainings in the CA3 but not in the DG, chronic treatment with FLX not only reversed the despaired behavior induced by exposure to LH paradigm, but also fully recovered SYN and PSD-95 labeling to control values.
Negative_regulation (recovered) of SYN associated with fluoxetine
1) Confidence 0.01 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.28 Pain Relevance 0.85
When FLX treatment was withdrawn for 90 days in those LH-FLX animals in which reversion of despair had been observed at day 25, recurrence of despaired behavior was found accompanied by decreased SYN, PSD-95, and NFL labelings.
Negative_regulation (decreased) of SYN associated with recurrence and fluoxetine
2) Confidence 0.01 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.23 Pain Relevance 0.79
Whereas LH animals treated 21 days with saline (LH-S group) displayed diminished SYN and PSD-95 immunostainings in the CA3 but not in the DG, chronic treatment with FLX not only reversed the despaired behavior induced by exposure to LH paradigm, but also fully recovered SYN and PSD-95 labeling to control values.
Negative_regulation (diminished) of SYN associated with fluoxetine
3) Confidence 0.01 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17955054 Disease Relevance 0.28 Pain Relevance 0.77

General Comments

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