INT147345

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.72
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
striatum 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 30 100.00 Very High Very High Very High
dopamine receptor 3 99.68 Very High Very High Very High
Enkephalin 8 98.78 Very High Very High Very High
Cannabinoid 5 97.92 Very High Very High Very High
projection neuron 4 95.52 Very High Very High Very High
Ventral tegmentum 1 93.84 High High
Substantia nigra 2 91.80 High High
Endocannabinoid 4 87.64 High High
substance P 6 76.20 Quite High
agonist 4 54.04 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 188 99.40 Very High Very High Very High
Skin Cancer 212 99.26 Very High Very High Very High
Apoptosis 117 98.28 Very High Very High Very High
Death 28 65.60 Quite High
Cancer 223 50.00 Quite Low
Targeted Disruption 14 39.44 Quite Low
Wiskott-aldrich Syndrome 27 5.00 Very Low Very Low Very Low
Disease 26 5.00 Very Low Very Low Very Low
Metastasis 16 5.00 Very Low Very Low Very Low
Solid Tumor 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors.
Localization (localization) of D1 in striatum associated with dopamine receptor and enkephalin
1) Confidence 0.50 Published 2008 Journal Neuropsychopharmacology Section Title Doc Link 17957223 Disease Relevance 0 Pain Relevance 0.95
Caspase 3/7 assays showed that both D1 and D6 (at 10 ?
Localization (at) of D1
2) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.11 Pain Relevance 0
Briefly, both MM and NB cell lines were untreated or treated with either D1 (10 ?
Localization (treated) of D1 associated with neuroblastoma and skin cancer
3) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.29 Pain Relevance 0
Cells were then treated with D1 or D6 at a concentration of 10 ?
Localization (treated) of D1
4) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.12 Pain Relevance 0
The cells were then treated with both D1 and D6 (2.5-10 ?
Localization (treated) of D1
5) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 0.21 Pain Relevance 0
These are antibodies B9 and D1, directed against epitopes within the N-terminal 250 amino acids, and W485, an antibody directed against residues 485-502.
Localization (directed) of D1
6) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0 Pain Relevance 0
Within the striatum, the postsynaptic effects of dopamine (DA) are mediated mainly by stimulation of D1 and D2 types of DA receptors (D1R and D2R) (Kebabian and Calne, 1979; Stoof and Kebabian, 1984) localized in MSNs (Hersch et al., 1995; Yung et al., 1995).
Localization (localized) of D1 in striatum associated with dopamine
7) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.43

General Comments

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