INT147349

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 7.83
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
bone marrow 2
colon 1
groove 1
AsPC-1 1
BxPC-3 1
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 24 98.52 Very High Very High Very High
Infliximab 35 96.52 Very High Very High Very High
Etanercept 31 96.20 Very High Very High Very High
cINOD 1 83.84 Quite High
anesthesia 7 81.72 Quite High
Nerve growth factor 1 80.80 Quite High
Thoracotomy 1 60.80 Quite High
isoflurane 4 57.44 Quite High
Buprenorphine 2 56.24 Quite High
Inflammation 37 54.24 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 637 100.00 Very High Very High Very High
Colon Cancer 5 97.80 Very High Very High Very High
Infection 156 97.20 Very High Very High Very High
Follicular Lymphoma 38 96.92 Very High Very High Very High
Colitis 36 93.96 High High
Viral Infection 40 91.20 High High
Targeted Disruption 72 90.92 High High
Injury 63 90.32 High High
Cancer 50 89.52 High High
Necrosis 18 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemically damaged cells undergo a p53-dependent apoptotic pathway that involves upregulation of p53 transcripts such as the pro-apoptotic Bcl2 family members and p53 translocation to the mitochondria, resulting in neutralization of the anti-apoptotic members Bcl-xL and Bcl-2 [26].
Localization (translocation) of Bcl2 associated with apoptosis
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.10 Pain Relevance 0
While it is often cited that the t(14; 18) translocation of the BCL-2 proto-oncogene is expressed in blood or bone marrow in 80% of patients with follicular lymphoma, the detection rate in recent phase II studies has been substantially lower, 40%–70% (Kaminski et al 2005; Press et al 2006; Jankowitz et al 2007).
Localization (translocation) of BCL-2 in bone marrow associated with follicular lymphoma
2) Confidence 0.50 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.23 Pain Relevance 0.03
HV68 viruses that express HA-tagged WT (referred to as HA-WT) or mutant forms of vBcl-2 including AAA, ??
Localization (referred) of vBcl-2
3) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
These data collectively demonstrate that the BH2 domain of the hydrophobic groove of vBcl-2 is not essential for suppressing Beclin1-mediated autophagy and its elimination does not affect Beclin1 binding, whereas the elimination of ?
Localization (groove) of vBcl-2 in groove
4) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
NIH3T3 cells stably expressing the WT or mutant forms of vBcl-2 were seeded at 1×106 cells per well into 6-well plates for 24 h.
Localization (forms) of vBcl-2
5) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.75 Pain Relevance 0
Immunohistochemical localization of nitrotyrosine, PARP, ICAM-1, P-Selectin, Bax, Bcl-2, TNF-?
Localization (localization) of Bcl-2
6) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0 Pain Relevance 0.03
DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.
Localization (release) of bcl-2 in colon associated with colon cancer and apoptosis
7) Confidence 0.32 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.70 Pain Relevance 0.12
Importantly, there was only a slight difference in cytochrome c release in the Bcl-2 over-expressing cells (Figure 4A), but this difference was statistically not significant (paired t-test).
Localization (release) of Bcl-2
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 0.59 Pain Relevance 0
Chemically damaged cells undergo a p53-dependent apoptotic pathway that involves upregulation of p53 transcripts such as the pro-apoptotic Bcl2 family members and p53 translocation to the mitochondria, resulting in neutralization of the anti-apoptotic members Bcl-xL and Bcl-2 [26].
Localization (translocation) of Bcl-2 associated with apoptosis
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944824 Disease Relevance 1.19 Pain Relevance 0
PCR remission was not correlated with clinical outcomes such as PFS or OS, although the power to detect a difference was low.43 In the study of fludarabine followed by 131I-TST, 13 patients had positive bone marrow PCR for the BCL-2 translocation.
Localization (translocation) of BCL-2 in bone marrow
10) Confidence 0.25 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.11 Pain Relevance 0
In separate experiments, mice pretreated with either rhBCL2 or rhBim were subjected to myocardial I/R.
Localization (pretreated) of rhBCL2
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.23 Pain Relevance 0.20
Similarly, in TNFR-1-/- mice, bcl-2 was preserved at both time-points (fig. 5 I,J).
Localization (preserved) of bcl-2
12) Confidence 0.22 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 1.04 Pain Relevance 0.49
Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.
Localization (release) of bcl-2 in BxPC-3 associated with qutenza
13) Confidence 0.15 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.95 Pain Relevance 0.72
Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.
Localization (release) of bcl-2 in AsPC-1 associated with qutenza
14) Confidence 0.05 Published 2008 Journal Apoptosis Section Abstract Doc Link 19002586 Disease Relevance 0.95 Pain Relevance 0.72

General Comments

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