INT14735

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Context Info
Confidence 0.42
First Reported 1991
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.13
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL6A2) extracellular region (COL6A2) proteinaceous extracellular matrix (COL6A2)
protein binding, bridging (COL6A2) extracellular matrix organization (COL6A2) protein complex (COL6A2)
Anatomy Link Frequency
dermis 2
COL6A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 22 79.88 Quite High
cytokine 2 70.16 Quite High
Pain 3 64.00 Quite High
Inflammation 4 51.64 Quite High
alcohol 9 33.28 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 4 100.00 Very High Very High Very High
Pressure And Volume Under Development 3 100.00 Very High Very High Very High
Diabetes Mellitus 4 99.86 Very High Very High Very High
Obesity 4 99.52 Very High Very High Very High
Fatty Liver 28 98.64 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 93 98.18 Very High Very High Very High
Injury 7 92.48 High High
Syndrome 10 90.80 High High
Myalgia 4 90.24 High High
Eosinophilia 4 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of type VI collagen mRNA, as evidenced by positive in situ hybridization signals with an alpha 2(VI) collagen cDNA, were also found in the fascia in comparison with the dermis.
Positive_regulation (Increased) of type VI collagen in dermis
1) Confidence 0.42 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.71 Pain Relevance 0.04
The immunohistochemical studies demonstrated increased deposition of TGF-beta, type VI collagen, and fibronectin epitopes in the extracellular matrix of the fascia in comparison to the adjacent dermis in the same specimens.
Positive_regulation (increased) of type VI collagen in dermis
2) Confidence 0.28 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.75 Pain Relevance 0.03
Different studies have shown that factors which are associated with NASH in patients with NAFLD are male gender, age, the extent of obesity, type 2 diabetes, high levels of alanine aminotransferase, aspartate aminotransferase and triglycerides, high HOMA indices of insulin resistance, systemic hypertension, high levels of C-peptide [6,16-21], hyaluronic acid and type VI collagen [22], TNF-alpha and IL-8 [23], and serum acute phase proteins [24].
Positive_regulation (levels) of type VI collagen associated with fatty liver, pressure and volume under development, nash(non-alcoholic steatohepatitis), diabetes mellitus, obesity and insulin resistance
3) Confidence 0.08 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.67 Pain Relevance 0.16

General Comments

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